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Titolo:
CORONAL SUTURE PATHOLOGY AND SYNOSTOTIC PROGRESSION IN RABBITS WITH CONGENITAL CRANIOSYNOSTOSIS
Autore:
MOONEY MP; SMITH TD; BURROWS AM; LANGDON HL; STONE CE; LOSKEN HW; CARUSO K; SIEGEL MI;
Indirizzi:
UNIV PITTSBURGH,DEPT ANAT & HISTOL,631 SALK HALL PITTSBURGH PA 15260 UNIV PITTSBURGH,DEPT ANTHROPOL PITTSBURGH PA 15260 UNIV PITTSBURGH,DEPT PLAST SURG PITTSBURGH PA 15260 UNIV PITTSBURGH,CLEFT PALATE CRANIOFACIAL CTR PITTSBURGH PA 15260 SLIPPERY ROCK UNIV,DEPT PHYS THERAPY SLIPPERY ROCK PA 16057 UNIV PITTSBURGH,DIV PLAST SURG PITTSBURGH PA 15260 CHILDRENS HOSP PITTSBURGH PA 00000 UNIV PITTSBURGH,DEPT BIOL PITTSBURGH PA 15260 UNIV PITTSBURGH,DEPT ORTHODONT PITTSBURGH PA 15260
Titolo Testata:
The Cleft palate-craniofacial journal
fascicolo: 5, volume: 33, anno: 1996,
pagine: 369 - 378
SICI:
1055-6656(1996)33:5<369:CSPASP>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CRANIAL SUTURES; OSSEOUS OBLITERATION; TISSUE INTERACTIONS; DURA-MATER; SKULL; GROWTH; MORPHOGENESIS; CALVARIA; ORIGIN; STRAIN;
Keywords:
ANIMAL MODEL; BONE CYTOKINES; CORONAL SUTURE; CRANIOSYNOSTOSIS; FETAL DEVELOPMENT; HYPEROSTOSIS; PATHOGENESIS; RABBITS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
M.P. Mooney et al., "CORONAL SUTURE PATHOLOGY AND SYNOSTOTIC PROGRESSION IN RABBITS WITH CONGENITAL CRANIOSYNOSTOSIS", The Cleft palate-craniofacial journal, 33(5), 1996, pp. 369-378

Abstract

The purpose of the present study was to describe coronal suture pathology and cross sectional synostotic progression in an inbred strain ofrabbits with congenital craniosynostosis, Calvaria from 102 perinatalrabbits (39 unaffected; 63 bilateral or unilateral synostosis) were collected at fetal days 21 (n = 12), 25 (n = 20), 27 (n = 22), 30 (term) (n = 32), and 3 days post-term (n = 16) for gross morphologic and histologic examination, Synostotic foci, the extent of relative bony bridging, and suture morphology were evaluated qualitatively and quantitatively. Of the 204 coronal sutures examined, 91 sutures were synostosed, and 113 were patent, All synostosed sutures showed similar foci by day 25, which originated as bony bridges in the middle of each suture on the ectocortic surface, Bony bridging width increased significantly(p < .001) from day 25 through 3 days post-term, and was best described by a linear regression equation, Osteogenic front areas of synostosed sutures were up to 2.5 times greater than patent sutures in term fetuses, Findings demonstrate that coronal suture synostosis in the congenital rabbit model (1) begins early during suture morphogenesis (before 25 days of gestation); (2) consistently radiates from a single focus corresponding to a normal interdigitating region (i,e., a high-tension environment); (3) varies in onset and rate as evidenced by low R(2)value between age and extent of bony bridging; and (4) is the result of early hyperostosis of the osteogenic fronts and sutural agenesis. Anumber of possible pathogenetic mechanisms are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:51:29