Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PRENATAL ALCOHOL EXPOSURE INFLUENCES THE EFFECTS OF NEUROACTIVE STEROIDS ON SEPARATION-INDUCED ULTRASONIC VOCALIZATIONS IN RAT PUPS
Autore:
ZIMMERBERG B; MCDONALD BC;
Indirizzi:
WILLIAMS COLL,BRONFMAN SCI CTR,DEPT PSYCHOL WILLIAMSTOWN MA 01267
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 4, volume: 55, anno: 1996,
pagine: 541 - 547
SICI:
0091-3057(1996)55:4<541:PAEITE>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADRENAL RESPONSES; GABA-A RECEPTORS; PREGNENOLONE-SULFATE; MEDIATED INCREASES; ETHANOL EXPOSURE; NEUROSTEROIDS; STRESS; ALLOPREGNANOLONE; POTENTIATION; PREGNANOLONE;
Keywords:
PREGNENOLONE SULFATE; 5-PREGNEN-3B-OL-20-ONE; ALCOHOL; NEUROACTIVE STEROIDS; ULTRASONIC VOCALIZATIONS; MATERNAL SEPARATION; FETAL ALCOHOL SYNDROME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
B. Zimmerberg e B.C. Mcdonald, "PRENATAL ALCOHOL EXPOSURE INFLUENCES THE EFFECTS OF NEUROACTIVE STEROIDS ON SEPARATION-INDUCED ULTRASONIC VOCALIZATIONS IN RAT PUPS", Pharmacology, biochemistry and behavior, 55(4), 1996, pp. 541-547

Abstract

Fetal alcohol exposure has been reported to be associated with hyper-responsiveness to stress. Using a maternal separation paradigm, this study examined whether prenatal alcohol exposure affected sensitivity to neurosteroid modulation of stress. We have shown that the neuroactive steroid allopregnanolone reduces ultrasonic vocalizations (USVs) after brief maternal separation in week-old rat pups. Prenatal alcohol exposure, however, resulted in reduced sensitivity to this neurosteroid. In this study's first experiment, the behavioral effects of pregnenolone sulfate, a neurosteroid with reportedly opposite modulatory effects on the GABA, receptor, were characterized, Pregnenolone sulfate had a triphasic effect on the production of ultrasonic vocalizations and on open field activity. Blockade of conversion of pregnenolone sulfate to allopregnanolone via the So-reductase inhibitor 4-MA also blocked the drug-related reduction in USVs. bur not the higher-dose augmentation. The enzyme inhibitor alone had no significant effects on USV production, nor did progesterone. These results suggest that the neuroactivesteroid pregnenolone sulfate may play an independent role in the stress response after maternal separation as well as being a precursor forthe anxiolytic neurosteroid allopregnanolone. In the second experiment, prenatal alcohol exposure was found to eliminate both the low dose USV-reducing effect and the higher dose USV-increasing effect. These results support previous results demonstrating that prenatal alcohol exposure may cause an altered sensitivity to the neuromodulatory effectsof neurosteroids. Copyright (C) 1996 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:13:14