Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
FAS ANTIGEN APO-1 (CD95) EXPRESSION ON MYELOMA CELLS/
Autore:
SHIMA Y; NISHIMOTO N; YOSHIZAKI K; KISHIMOTO T;
Indirizzi:
OSAKA UNIV,SCH MED,DEPT MED 3,2-2 YAMADA OKA SUITA OSAKA 565 JAPAN
Titolo Testata:
Leukemia & lymphoma
fascicolo: 5-6, volume: 23, anno: 1996,
pagine: 521 -
SICI:
1042-8194(1996)23:5-6<521:FAA(EO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; NEMATODE CAENORHABDITIS-ELEGANS; DEATH GENE CED-3; MULTIPLE-MYELOMA; B-CELLS; FACTOR ADF; C-ELEGANS; SURFACE ANTIGEN; TRANSGENIC MICE; BONE-MARROW;
Keywords:
MYELOMA; APOPTOSIS; FAS ANTIGEN APO-1 (CD95); BCL-2;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
92
Recensione:
Indirizzi per estratti:
Citazione:
Y. Shima et al., "FAS ANTIGEN APO-1 (CD95) EXPRESSION ON MYELOMA CELLS/", Leukemia & lymphoma, 23(5-6), 1996, pp. 521

Abstract

Many factors involved in the proliferation of myelomas have been reported, and the relationship between these factors and the pathogenesis of multiple myeloma has been discussed. We found that most myeloma cells express Fas antigen/APO-1 (CD95), a cell surface antigen that mediates apoptosis. However only some cells are sensitive to anti-Fas antibody and undergo apoptosis. These data indicate that some multiple myelomas are generated not only by cell proliferation but also by cell immortalization The mechanism by which myelomas are immortalized is stillunclear, but Bcl-2, Bcl-x(L), adult T cell leukemia derived factor (ADF), soluble Pas are all candidate factors for this mechanism. The possibility als, exists that inducers of apoptosis, e.g. tumor necrosis factor(TNF), interleukin-1 beta-converting enzyme(ICE), Bcl-x(S), or Bar, do not have a lethal effect. In this review, we focus on the systemthat immortalizes myeloma cells, and suggest the possibility that multiple myeloma constitutes one group of cells which cannot undergo apoptosis in the bone marrow.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 07:46:50