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Titolo:
EVIDENCE FOR MU(1)-OPIOID RECEPTOR INVOLVEMENT IN FENTANYL-MEDIATED RESPIRATORY DEPRESSION
Autore:
CHEN SW; MAGUIRE PA; DAVIES MF; BEATTY MF; LOEW GH;
Indirizzi:
MOL RES INST,845 PAGE MILL RD PALO ALTO CA 94304 MOL RES INST PALO ALTO CA 94304 UNIV BATH,SCH PHARM & PHARMACOL BATH BA2 7AY AVON ENGLAND
Titolo Testata:
European journal of pharmacology
fascicolo: 2, volume: 312, anno: 1996,
pagine: 241 - 244
SICI:
0014-2999(1996)312:2<241:EFMRII>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
OPIOID ANALGESIA; NALOXONAZINE; STIMULATION; DERMORPHIN; AGONIST;
Keywords:
MU(1)-OPIOID RECEPTOR; RESPIRATORY DEPRESSION; FENTANYL; MORPHINE; MUSCLE RIGIDITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
S.W. Chen et al., "EVIDENCE FOR MU(1)-OPIOID RECEPTOR INVOLVEMENT IN FENTANYL-MEDIATED RESPIRATORY DEPRESSION", European journal of pharmacology, 312(2), 1996, pp. 241-244

Abstract

Several fentanyl analogs (Bagley et al., 1989, J. Med. Chem. 32, 663)were compared to fentanyl and morphine for their effects on respiratory depression as determined by arterial blood gas (pH, pCO(2) and pO(2)) measurements. Fentanyl (0.1 mg/kg), morphine (10 mg/kg), #16 n-2-yl)-N-(methoxymethylcarbonyl)amino]piperidine, 1 mg/kg), #17 -4-[N-(pyridin-2-yl)-N-(2-furoyI)amino]piperidine, 0.5 mg/kg) and #29 -yl)-N-(methoxy-mehtylcarbonylyl)amino]piperidine, 10 mg/kg) produced significantrespiratory depression in rats. Pretreatment with the mu(1)-opioid receptor selective antagonist, naloxonazine (10 mg/kg), blocked the respiratory effect of fentanyl and its analogs, but not that of morphine. The results suggest that the mu(1)-opioid receptor plays an important role in the respiratory effects of fentanyl and its analogs. Hence, the mechanism of fentanyl-induced respiratory depression appears to be distinct from that produced by morphine. The most likely explanation for this difference is the possible contribution of muscle rigidity and catalepsy to the observed changes in blood gas parameters caused by the fentanyl analogs, while the respiratory depression of morphine, measured by these same parameters, appears to be independent of its effecton muscle rigidity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 10:31:44