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Titolo:
MATRIX METALLOPROTEINASES AND THEIR INHIBITORS IN GINGIVAL CREVICULARFLUID AND SALIVA OF PERIODONTITIS PATIENTS
Autore:
INGMAN T; TERVAHARTIALA T; DING YL; TSCHESCHE H; HAERIAN A; KINANE DF; KONTTINEN YT; SORSA T;
Indirizzi:
UNIV HELSINKI,INST DENT,DEPT PEDODONT & ORTHODONT,POB 41 FIN-00014 HELSINKI FINLAND UNIV HELSINKI,DEPT ANAT FIN-00014 HELSINKI FINLAND UNIV HELSINKI,DEPT PERIODONTOL FIN-00014 HELSINKI FINLAND UNIV HELSINKI,DEPT MED CHEM FIN-00014 HELSINKI FINLAND UNIV HELSINKI,DEPT MED 4 FIN-00014 HELSINKI FINLAND UNIV BIELEFELD,DEPT BIOCHEM D-4800 BIELEFELD GERMANY UNIV GLASGOW,DEPT PERIODONTOL GLASGOW LANARK SCOTLAND
Titolo Testata:
Journal of clinical periodontology
fascicolo: 12, volume: 23, anno: 1996,
pagine: 1127 - 1132
SICI:
0303-6979(1996)23:12<1127:MMATII>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMORPHONUCLEAR LEUKOCYTE COLLAGENASE; JUVENILE PERIODONTITIS; INTERSTITIAL COLLAGENASES; TETRACYCLINE INHIBITION; ADULT PERIODONTITIS; TISSUE DESTRUCTION; HUMAN NEUTROPHIL; CELLULAR SOURCE; SULCULAR FLUID; IN-VIVO;
Keywords:
ADULT PERIODONTITIS; ELISA; GINGIVAL CREVICULAR FLUID; LOCALIZED JUVENILE PERIODONTITIS; MATRIX METALLOPROTEINASES; SALIVA; TISSUE INHIBITOR OF MATRIX METALLOPROTEINASES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
T. Ingman et al., "MATRIX METALLOPROTEINASES AND THEIR INHIBITORS IN GINGIVAL CREVICULARFLUID AND SALIVA OF PERIODONTITIS PATIENTS", Journal of clinical periodontology, 23(12), 1996, pp. 1127-1132

Abstract

Matrix metalloproteinases (MMPs) and serine proteinases seem to be related to tissue destruction in periodontitis. The presence of MMPs in gingival crevicular fluid (GCF) and saliva, however, has not been studied comprehensively with the enzyme-linked immunosorbent assay (ELISA)-technique, We therefore examined the levels of MMP-1, -3, -8 and -9, and their endogenous inhibitor, tissue inhibitor of matrix metalloproteinases (TIMP-1), in GCF and saliva of patients with adult periodontitis (AP) and localized juvenile periodontitis (LJP). Elevated levels ofMMP-1 were detected in LJP GCF compared to AP and control GCE Elevated levels of TIMP-1 were also detected in LJP GCF in comparison to AP and control GCE Higher MMP-8 levels were detected in AP GCF compared toLJP and control GCE The relative low levels of MMP-3 were present in all studied GCF samples. Elevated levels of MMP-8 were further detected in saliva of AP compared to LJP and the controls. Both MMP-1 and TIMP-1 were detected in all studied saliva samples, but not significant differences were detected between the studied groups. Our ELISA-resultsconfirm that (i) PMN MMP-8 and MMP-9 are the main collagenase and gelatinase in AP GCF, whereas GCF collagenase in LJP seems to be of the MMP-1-type; (ii) only low levels of TIMP-1, endogenous MMP-inhibitor, are present in AP GCE which emphasises the importance of doxycycline asa possible adjunctive drug in the treatment of AP patients; (iii) tests based on specific antibodies against PMN MMPs, especially MMP-8, might serve as a reliable method of measuring and monitoring enzyme levels in GCF from different periodontitis patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 05:38:28