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Titolo:
ONE-WEEK LOW-DOSE TRIPLE THERAPY VS 2-WEEK MEDIUM-DOSE DOUBLE THERAPYFOR HELICOBACTER-PYLORI INFECTION
Autore:
TURSI A; CAMMAROTA G; PAPA A; MONTALTO M; VENETO G; CAPELLI G; CUOCO L; BRANCA G; FEDELI G; GASBARRINI G;
Indirizzi:
UNIV CATTOLICA SACRO CUORE,POLICLIN A GEMELLI,GASTROENTEROL SERV,LARGO A GEMELLI 8 I-00168 ROME ITALY CATHOLIC UNIV SC,INST MICROBIOL ROME ITALY CATHOLIC UNIV SC,INST HYG ROME ITALY CATHOLIC UNIV SC,DEPT INTERNAL MED,DIV GASTROENTEROL ROME ITALY
Titolo Testata:
Hepato-gastroenterology
fascicolo: 10, volume: 43, anno: 1996,
pagine: 859 - 862
SICI:
0172-6390(1996)43:10<859:OLTTV2>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
OMEPRAZOLE PLUS AMOXICILLIN; PEPTIC-ULCER DISEASE; ERADICATE HELICOBACTER-PYLORI; CAMPYLOBACTER-PYLORI; SUSCEPTIBILITY; CLARITHROMYCIN; EFFICACY; CURE;
Keywords:
HELICOBACTER PYLORI; AMOXICILLIN; CLARITHROMYCIN; DOUBLE THERAPY; OMEPRAZOLE; TINIDAZOLE; TRIPLE THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
A. Tursi et al., "ONE-WEEK LOW-DOSE TRIPLE THERAPY VS 2-WEEK MEDIUM-DOSE DOUBLE THERAPYFOR HELICOBACTER-PYLORI INFECTION", Hepato-gastroenterology, 43(10), 1996, pp. 859-862

Abstract

Background/Aims: Our study is to compare a shortterm low-dose triple therapy with a Long-term medium-dose double therapy for H. pylori eradication. Materials and Methods: One hundred and ten consecutive patients, suffering from dyspeptic symptoms, with H. pylori infection, were randomly allocated to one of the following 2 groups with different therapeutic regimens: A) omeprazole 20 mg/day for 7 days, tinidazole 500 mg bid for 7 days, clarithromycin 250 mg bid for 7 days (55 pts, 20 with peptic ulcer); B) omeprazole 20 mg bid for 14 days, amoxycillin. 1000 mg bid for 14 days (55 pts, 28 with peptic ulcer). The ''H.pylori status'' was evaluated by means of histology, culture and crease test, at entry and 8 weeks after treatment. Results: Two group A and one group B pts didn't complete the treatment. The H.pylori eradication was obtained in 38 pts of group A (71.69%) (C.I.95%: 55.19176-80.86293), in31 of group B (58.49%) (C.I.95%: 42.32777-69.7017); on. Intention-to-Treat analysis, the rate of-eradication gave similar results. Side effects occurred in 9 pts of group A (16.98%), in 8 of group B (14.81%). Conclusions: Short-term low-dose triple therapy with omeprazole/tinidazole/clarithromycin has a better cost/benefit ratio than long-term dual therapy with omeprazole/amoxycillin in the H.pylori eradication, butit causes more side-effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 19:58:25