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Titolo:
EXTRAPYRAMIDAL SYNDROMES - EPIDEMIOLOGY, PATHOPHYSIOLOGY AND THE DIAGNOSTIC DILEMMA
Autore:
CASEY DE;
Indirizzi:
VET ADM MED CTR,PSYCHIAT SERV 116A,3710 SW US VET HOSP RD PORTLAND OR97207 OREGON HLTH SCI UNIV,DEPT PSYCHIAT PORTLAND OR 97201 OREGON HLTH SCI UNIV,DEPT NEUROL PORTLAND OR 97201 VET AFFAIRS MED CTR,SECT PSYCHIAT RES PORTLAND OR 00000 VET AFFAIRS MED CTR,SECT PSYCHOPHARMACOL PORTLAND OR 00000 OREGON REG PRIMATE RES CTR BEAVERTON OR 97006
Titolo Testata:
CNS DRUGS
, volume: 5, anno: 1996, supplemento:, 1
pagine: 1 - 12
SICI:
1172-7047(1996)5:<1:ES-EPA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROLEPTIC-INDUCED AKATHISIA; D2-DOPAMINE RECEPTOR OCCUPANCY; TARDIVE-DYSKINESIA; CEBUS MONKEYS; RATING-SCALE; HALOPERIDOL ANTAGONISTS; DOUBLE-BLIND; CLOZAPINE; SCHIZOPHRENIA; RACLOPRIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
D.E. Casey, "EXTRAPYRAMIDAL SYNDROMES - EPIDEMIOLOGY, PATHOPHYSIOLOGY AND THE DIAGNOSTIC DILEMMA", CNS DRUGS, 5, 1996, pp. 1-12

Abstract

Antipsychotics are the mainstay of treatment for acute and chronic psychosis, but these drugs have many troublesome neurological adverse effects. Extrapyramidal syndromes (EPS) of akathisia, dystonia and parkinsonism occur in a majority of patients receiving short and long term antipsychotic therapy. Tardive dyskinesia occurs in 15 to 20% of patients, but may have a much higher prevalence in the elderly. Patient anddrug factors strongly influence the risk of the motor and mental aspects of movement disorders. Dopamine, acetylcholine and serotonin (5-hydroxytryptamine; 5-HT) receptor antagonism play important roles in thepathophysiology of EPS. Each EPS has its own unique characteristics that must be considered in a differential diagnosis. Assessment approaches include a careful clinical assessment, systematic use of rating scales, and possibly the use of specialised equipment. Recognition and management of EPS with anti-EPS medicines or antipsychotic dose adjustments early in treatment will substantially reduce treatment-related adverse effects and improve therapeutic efficacy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 07:03:30