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Titolo:
PROTECTION AGAINST PEROXYNITRITE-DEPENDENT TYROSINE NITRATION AND ALPHA-1-ANTIPROTEINASE INACTIVATION BY ASCORBIC-ACID - A COMPARISON WITH OTHER BIOLOGICAL ANTIOXIDANTS
Autore:
WHITEMAN M; HALLIWELL B;
Indirizzi:
UNIV LONDON KINGS COLL,NEURODEGENERAT DIS RES CTR,PHARMACOL GRP,MANRESA RD LONDON SW3 6LX ENGLAND UNIV LONDON KINGS COLL,NEURODEGENERAT DIS RES CTR,PHARMACOL GRP LONDON SW3 6LX ENGLAND
Titolo Testata:
Free radical research
fascicolo: 3, volume: 25, anno: 1996,
pagine: 275 - 283
SICI:
1071-5762(1996)25:3<275:PAPTNA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXIDATIVE DAMAGE; SYNOVIAL-FLUID; NITRIC-OXIDE; URIC-ACID; RHEUMATOID PATIENTS; FREE-RADICALS; HUMAN PLASMA; SUPEROXIDE; DEPLETION; NITROTYROSINE;
Keywords:
PEROXYNITRITE; ASCORBATE; TYROSINE NITRATION; ALPHA(1)-ANTIPROTEINASE; REACTIVE NITROGEN SPECIES; RHEUMATOID ARTHRITIS; METHIONINE; GSH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
M. Whiteman e B. Halliwell, "PROTECTION AGAINST PEROXYNITRITE-DEPENDENT TYROSINE NITRATION AND ALPHA-1-ANTIPROTEINASE INACTIVATION BY ASCORBIC-ACID - A COMPARISON WITH OTHER BIOLOGICAL ANTIOXIDANTS", Free radical research, 25(3), 1996, pp. 275-283

Abstract

Peroxynitrite, formed by reaction of superoxide and nitric oxide, appears to be an important tissue-damaging species generated at sites of inflammation. In this paper, we compare the abilities of several biological antioxidants to protect against peroxynitrite-dependent inactivation of alpha(1)-antiproteinase, and to inhibit tyrosine nitration upon addition of peroxynitrite. GSH and ascorbate protected efficiently in both systems. Uric acid inhibited tyrosine nitration but not alpha(1)-antiproteinase inactivation. The possibility that ascorbic acid is an important scavenger of reactive nitrogen species in vivo is discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:27:15