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Titolo:
CA2-40116 AND CGP-43487, IN MICE( CHANNEL BLOCKADE AND THE ANTIELECTROSHOCK ACTIVITY OF NMDA RECEPTOR ANTAGONISTS, CGP)
Autore:
GASIOR M; BOROWICZ K; STAROWNIK R; KLEINROK Z; CZUCZWAR SJ;
Indirizzi:
SCH MED,DEPT PHARMACOL & TOXICOL,JACZEWSKIEGO 8 PL-20090 LUBLIN POLAND SCH MED,DEPT PHARMACOL & TOXICOL PL-20090 LUBLIN POLAND
Titolo Testata:
European journal of pharmacology
fascicolo: 1, volume: 312, anno: 1996,
pagine: 27 - 33
SICI:
0014-2999(1996)312:1<27:CACIMC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTICONVULSANT ACTIVITY; ANTIEPILEPTIC DRUGS; BAY K-8644; HIPPOCAMPAL-NEURONS; INDUCED CONVULSIONS; CALCIUM; AGONIST; EPILEPSY; EFFICACY; ELECTROCONVULSIONS;
Keywords:
NMDA RECEPTOR ANTAGONIST; CGP 40116; CGP 43487; CA2+ CHANNEL INHIBITOR; FLUNARIZINE; NICARDIPINE; NIFEDIPINE; SEIZURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
M. Gasior et al., "CA2-40116 AND CGP-43487, IN MICE( CHANNEL BLOCKADE AND THE ANTIELECTROSHOCK ACTIVITY OF NMDA RECEPTOR ANTAGONISTS, CGP)", European journal of pharmacology, 312(1), 1996, pp. 27-33

Abstract

Nicardipine, nifedipine and flunarizine showed anticonvulsive activity (reflected by significant elevations of the seizure threshold for tonic hindlimb extension) in doses of 20, 20 and 15 mg/kg, respectively. In combination studies, CGP 40116 [D-(E)-2-amino-4-methyl5-phosphono-3-pentenoic acid] or its methyl ester derivative (CGP 43487) was administered in a constant dose of 0.25 and 3.5 mg/kg, respectively. At these doses both competitive NMDA receptor antagonists were able to elevate significantly the convulsive threshold. Nicardipine, nifedipine, and flunarizine were administered at maximal doses (or lower) not affecting the convulsive threshold(15, 15 and 10 mg/kg, respectively). The protective activity of CGP 40116 and CGP 43487 was dose dependently potentiated by all three Ca2+ channel inhibitors. The combined treatment caused motor impairments (evaluated in the chimney test) and long-termmemory deficits (measured in the passive avoidance task) similar to these produced by CGP 40116 or CGP 43487 alone. Our results indicate that nicardipine, nifedipine and flunarizine significantly potentiate the protective activity, but not the adverse effects, of CGP 40116 and CGP 43487 in mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 04:12:01