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Titolo:
THE EFFECT OF AGING AND DIETARY RESTRICTION ON THE RETINOYLATION OF NUCLEAR MATRIX PROTEINS IN RATS
Autore:
PIPKIN JL; HINSON W; LYNCOOK LE; DUFFY PH; FEUERS RJ; LEAKEY JEA; ALY KB; HART RW; CASCIANO DA;
Indirizzi:
NATL CTR TOXICOL RES,DIV GENET TOXICOL,HFT-120,3900 NC-TR RD JEFFERSON AR 72079
Titolo Testata:
Aging
fascicolo: 4, volume: 8, anno: 1996,
pagine: 263 - 270
SICI:
0394-9532(1996)8:4<263:TEOAAD>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINOIC ACID; CALORIC RESTRICTION; STRESS PROTEINS; POLYACRYLAMIDE GELS; CELL; LEUKEMIA; PHOSPHORYLATION; INDUCTION; HL-60;
Keywords:
AGING; DIET RESTRICTION; NUCLEAR MATRIX PROTEINS; RETINOYLATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Pipkin et al., "THE EFFECT OF AGING AND DIETARY RESTRICTION ON THE RETINOYLATION OF NUCLEAR MATRIX PROTEINS IN RATS", Aging, 8(4), 1996, pp. 263-270

Abstract

The labeling in vivo of young ad libitum (Y/AL) and old diet restricted (O/DR) rats with [H-3]retinoic acid (RA) for 6 hours, and the exposure of electrophoretically separated nuclear matrix proteins from bonemarrow tissue on film for 48 days revealed the presence of eleven retinoylated proteins. Dosing with RA (100 mg/kg body weight;) for 96 hours and exposure to [H-3]RA enhanced the levels of radioactive incorporation of several nuclear matrix proteins, including p51, and p55, similarly in Y/AL and O/DR rats. Dosing of old ad libitum (O/AL) rats with[H-3]RA for 6 hours showed the incorporation of six proteins following 48 days of exposure on film. Long-term dosing of RA (96 hours) did not increase [H-3]RA incorporation in these proteins, including p51 andp55, in O/AL rats. Increasing the level of RA by two-fold (200 mg/kg body weight;) in Y/AL and O/DR rats elicited an increase in the incorporation levels of [H-3]R4 in five proteins. This dose response following increased levels of RA was not seen in the retinoylated proteins ofO/AL animals. Analysis by the Western blotting technique showed p51 and p55 from rat bone marrow cells to have the same immunochemical determinates with proteins of identical molecular masses in HL60 cells. The levels of retinoylation of nuclear matrix proteins in O/DR animals, altered by age- and diet-dependent factors, suggests a condition that is more reminiscent of Y/AL than of O/AL animals. (C)1994, Editrice Kurtis

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Documento generato il 28/03/20 alle ore 23:32:08