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Titolo:
ALTERATION AND RECOVERY OF THE SPATIAL ORIENTATION OF THE COLLAGEN NETWORK OF ARTICULAR-CARTILAGE IN ADOLESCENT RABBITS FOLLOWING INTRAARTICULAR CHYMOPAPAIN INJECTION
Autore:
WILLIAMS JM; UEBELHART D; THONAR EJMA; KOCSIS K; MODIS L;
Indirizzi:
RUSH PRESBYTERIAN ST LUKES MED CTR,DEPT ANAT,RUSH MED COLL,600 S PAULINA ST CHICAGO IL 60612 RUSH PRESBYTERIAN ST LUKES MED CTR,DEPT BIOCHEM,RUSH MED COLL CHICAGOIL 60612 RUSH PRESBYTERIAN ST LUKES MED CTR,DEPT INTERNAL MED,RUSH MED COLL,RHEUMATOL SECT CHICAGO IL 60612 HOP CANTONAL UNIV GENEVA,DEPT MED PHYS & REEDUC GENEVA SWITZERLAND DEBRECEN UNIV MED,SCH MED,DEPT ANAT HISTOL & EMBRYOL H-4012 DEBRECEN HUNGARY
Titolo Testata:
Connective tissue research
fascicolo: 2, volume: 34, anno: 1996,
pagine: 105 - 117
SICI:
0300-8207(1996)34:2<105:AAROTS>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
MATRIX BREAKDOWN; SECTIONS; MODEL;
Keywords:
ARTICULAR CARTILAGE REPAIR; POLARIZATION MICROSCOPY; COLLAGEN NETWORK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Williams et al., "ALTERATION AND RECOVERY OF THE SPATIAL ORIENTATION OF THE COLLAGEN NETWORK OF ARTICULAR-CARTILAGE IN ADOLESCENT RABBITS FOLLOWING INTRAARTICULAR CHYMOPAPAIN INJECTION", Connective tissue research, 34(2), 1996, pp. 105-117

Abstract

We have used polarized light (POL) to monitor changes in the organization of the articular cartilage collagen network and matrix proteoglycans (PGs) after intra-articular injection of chymopapain (CP), POL viewing of sirius red stained sections revealed a loss of normal birefringence suggesting an apparent collapse of the collagen network following intra-articular CP, After 21 days, knees injected with 2.0 mg CP showed no return of normal birefringence, however, normal birefringence was noted in knees injected with only 0.2 mg CP, POL viewing of toluidine blue stained sections revealed a severe loss of matrix PGs followedby PG restoration in animals injected with 0.2 mg CP, The most important inference from the data is that articular cartilage can recover from enzyme-induced alterations in the spatial collapse of its fibrillarnetwork, This is an important finding since it has often been inferred that damage to the collagen network leads invariably to progressive articular cartilage destruction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:38:19