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Titolo:
FACTORS INFLUENCING TREATMENT RESPONSE AND OUTCOME OF FIRST-EPISODE SCHIZOPHRENIA - IMPLICATIONS FOR UNDERSTANDING THE PATHOPHYSIOLOGY OF SCHIZOPHRENIA
Autore:
LIEBERMAN JA; KOREEN AR; CHAKOS M; SHEITMAN B; WOERNER M; ALVIR JMJ; BILDER R;
Indirizzi:
UNIV N CAROLINA,SCH MED,DEPT PSYCHIAT CHAPEL HILL NC 27599 ALBERT EINSTEIN COLL MED,HILLSIDE HOSP,LONG ISL JEWISH MED CTR GLEN OAKS NY 00000
Titolo Testata:
The Journal of clinical psychiatry
, volume: 57, anno: 1996, supplemento:, 9
pagine: 5 - 9
SICI:
0160-6689(1996)57:<5:FITRAO>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
HOMOVANILLIC-ACID LEVELS; CAUDATE NUCLEI VOLUMES; 1ST-EPISODE SCHIZOPHRENIA; EXTRAPYRAMIDAL SYMPTOMS; TARDIVE-DYSKINESIA; BRAIN MORPHOLOGY; HALOPERIDOL; PSYCHOPATHOLOGY; PREDICTORS; PREVALENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Lieberman et al., "FACTORS INFLUENCING TREATMENT RESPONSE AND OUTCOME OF FIRST-EPISODE SCHIZOPHRENIA - IMPLICATIONS FOR UNDERSTANDING THE PATHOPHYSIOLOGY OF SCHIZOPHRENIA", The Journal of clinical psychiatry, 57, 1996, pp. 5-9

Abstract

For the majority of patients, schizophrenia is a chronic recurrent disease that leads to significant residual morbidity which occurs through a process of behavioral deterioration. The factors that influence the course of schizophrenia after its onset and the ability of treatmentto modify the effects of the patient's illness are not well understood. This article examines specific clinical and biological variables that are associated with treatment response and outcome. These variables, which are both trait and state dependent, include premorbid adjustment, age and mode of onset of illness, gender, duration of psychosis, schizophrenia subtype, primary negative symptoms, and extrapyramidal signs including tardive dyskinesia and plasma HVA and brain pathomorphology. In addition, the chronic effects of antipsychotic drug treatment may influence illness course both favorably and adversely as well as potentially altering the neurobiological substrates that mediate expression of the illness and treatment response. Finally, the question of whether the active phase of the illness involves a pathologic process that leads to illness progression is discussed. In light of this discussion, we can speculate that although certain aspects of the illness interms of its severity and course may be, to an extent, predetermined,a number of factors can exert favorable and unfavorable effects on the course of the illness and its ultimate outcome. One question for thefield is to develop therapeutic strategies that minimize the morbidity of the illness in a way that does not introduce iatrogenic consequences to the patient.

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Documento generato il 18/01/20 alle ore 01:54:34