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Titolo:
HIGH-LEVELS OF LP(A) LIPOPROTEIN IN A FAMILY WITH CASES OF SEVERE PREECLAMPSIA
Autore:
HUSBY H; ROALD B; SCHJETLEIN R; NESHEIM BI; BERG K;
Indirizzi:
ULLEVAL UNIV HOSP,DEPT OBSTET & GYNAECOL,KIRKEVEIEN 166 N-0407 OSLO NORWAY ULLEVAL UNIV HOSP,DEPT PATHOL OSLO NORWAY ULLEVAL UNIV HOSP,HEMATOL RES LAB OSLO NORWAY UNIV OSLO,INST MED GENET N-0316 OSLO NORWAY ULLEVAL UNIV HOSP,DEPT MED GENET OSLO NORWAY
Titolo Testata:
Clinical genetics
fascicolo: 1, volume: 50, anno: 1996,
pagine: 47 - 49
SICI:
0009-9163(1996)50:1<47:HOLLIA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREECLAMPSIA; PREGNANCY;
Keywords:
LP(A); PLACENTAL INSUFFICIENCY; PREECLAMPSIA; RISK FACTORS; VASCULAR DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
H. Husby et al., "HIGH-LEVELS OF LP(A) LIPOPROTEIN IN A FAMILY WITH CASES OF SEVERE PREECLAMPSIA", Clinical genetics, 50(1), 1996, pp. 47-49

Abstract

We report a family with two cases of severe pre-eclampsia/eclampsia in which very high levels of Lp(a) lipoprotein were found. The serum level of Lp(a) lipoprotein is genetically determined and the Lp(a) apolipoprotein has a close homology to plasminogen. Very high levels of Lp(a) lipoprotein might interfere with the fibrinolytic/thrombolytic process in man. A previous report suggested that a high maternal serum Lp(a) lipoprotein level can cause fetal growth retardation, and it is proposed that very high levels might lead to increased deposition of fibrin in the uterine spiral arteries in pregnancy, which is central in the pathogenesis of pre-eclampsia. If confirmed, a very high Lp(a) lipoprotein level could be one risk factor for pre-eclampsia that is genetically determined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:01:19