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Titolo:
MRI BRAIN ABNORMALITIES IN CHRONIC-SCHIZOPHRENIA - ONE PROCESS OR MORE
Autore:
WOODS BT; YURGELUNTODD D; GOLDSTEIN JM; SEIDMAN LJ; TSUANG MT;
Indirizzi:
VET ADM MED CTR,NEUROL SECT,1901 S 1ST ST TEMPLE TX 76504 TEXAS A&M UNIV,SCH MED,DEPT NEUROL TEMPLE TX 76508 TEXAS A&M UNIV,SCH MED,DEPT PSYCHIAT TEMPLE TX 76508 HARVARD UNIV,SCH MED,DEPT PSYCHIAT BELMONT MA 02178 MCLEAN HOSP,MAILMAN RES CTR,BRAIN IMAGING CTR BELMONT MA 02178 HARVARD UNIV,INST PSYCHIAT EPIDEMIOL & GENET BOSTON MA 00000 HARVARD UNIV,MASSACHUSETTS MENTAL HLTH CTR,DEPT PSYCHIAT BOSTON MA 02115 BROCKTON W ROXBURY VET AFFAIRS MED CTR BROCKTON MA 00000 HARVARD UNIV,SCH PUBL HLTH,DEPT EPIDEMIOL BOSTON MA 02115
Titolo Testata:
Biological psychiatry
fascicolo: 7, volume: 40, anno: 1996,
pagine: 585 - 596
SICI:
0006-3223(1996)40:7<585:MBAIC->2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
GRAY-MATTER VOLUME; FOLLOW-UP; CEREBROSPINAL-FLUID; STRUCTURAL ABNORMALITIES; VENTRICULAR ENLARGEMENT; CORTICAL DEVELOPMENT; TEMPORAL-LOBE; CEREBRAL GRAY; MORPHOLOGY; CT;
Keywords:
SCHIZOPHRENIA; MRI; BRAIN IMAGING; FRONTAL LOBES; TEMPORAL LOBES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
63
Recensione:
Indirizzi per estratti:
Citazione:
B.T. Woods et al., "MRI BRAIN ABNORMALITIES IN CHRONIC-SCHIZOPHRENIA - ONE PROCESS OR MORE", Biological psychiatry, 40(7), 1996, pp. 585-596

Abstract

It has been suggested that schizophrenia is primarily a prefrontal-temporal-limbic circuitry disorder. Further, it has been argued that primary neurologic vulnerability to the illness is established only during early stages of brain development and is not progressive. We tested the hypothesis of whether brain volume losses in prefrontal and temporal-limbic regions have occurred either before or after brain growth was hypothesized to be complete in schizophrenia Nineteen chronic schizophrenic patients and 19 age- and sex-matched normal controls underwentmagnetic resonance imaging (MRI). All scans were segmented into gray and white matter and cerebrospinal fluid (CSF) compartments for the frontal and temporal lobes and posterior cerebral hemispheres. Multivariate analysis of variance was used to analyze absolute intracranial cerebrum and subregion volumes, i.e., gray, white and CSF, absolute tissue (i.e., gray plus white) volumes, and tissue to intracranial volume (TCV) ratios. Patients showed significant intracranial volume reductions only in the frontal lobes but highly significantly lower TCV ratios (i.e., greater relative tissue loss) in all three major regions. It issuggested that the observed decreases in frontal intracranial volumesreflect a pathologic process in schizophrenia that impacted the frontal regions before brain growth was complete. We hypothesize that the generalized lower patient TCV ratios are attributable to a process thataffected the whole cerebrum over a time period after brain volume hadreached its maximum levels.

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Documento generato il 07/07/20 alle ore 06:01:38