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Titolo:
MHC CLASS-II MOLECULES ARE NOT REQUIRED FOR SURVIVAL OF NEWLY GENERATED CD4(-CELLS, BUT AFFECT THEIR LONG-TERM LIFE-SPAN() T)
Autore:
TAKEDA S; RODEWALD HR; ARAKAWA H; BLUETHMANN H; SHIMIZU T;
Indirizzi:
KYOTO UNIV,SCH MED,DEPT MOL IMMUNOL KYOTO 60601 JAPAN BASEL INST IMMUNOL CH-4005 BASEL SWITZERLAND F HOFFMANN LA ROCHE & CO LTD CH-4070 BASEL SWITZERLAND
Titolo Testata:
Immunity
fascicolo: 3, volume: 5, anno: 1996,
pagine: 217 - 228
SICI:
1074-7613(1996)5:3<217:MCMANR>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR TRANSGENIC MICE; POSITIVE SELECTION; MONOCLONAL-ANTIBODY; LYMPHOCYTES-T; SCID MICE; THYMUS; THYMOCYTES; MEMORY; DELETION; MODEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
S. Takeda et al., "MHC CLASS-II MOLECULES ARE NOT REQUIRED FOR SURVIVAL OF NEWLY GENERATED CD4(-CELLS, BUT AFFECT THEIR LONG-TERM LIFE-SPAN() T)", Immunity, 5(3), 1996, pp. 217-228

Abstract

We grafted fetal thymi from wild-type mice into immunodeficient RAG-2(-/-) or class II(-/-)RAG-2(-/-) (class II MHC(-)) recipients and followed the fate of naive CD4(+) T cells derived from the grafts. In bothtypes of recipients, newly generated CD4(+) T cells proliferated to the same extent in the periphery and rapidly filled the empty T cell compartment. However, CD4(+) T cells in class II- recipients gradually decreased in number over 6 months. These results show that interactionsbetween the TCR and class II molecules are not required for newly generated CD4(+) T cells to survive and proliferate, but are necessary tomaintain the size of the peripheral T cell pool for extended periods.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 10:07:41