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Titolo:
ENANTIOSELECTIVE SYNTHESIS OF A PYRROLO-BENZOTHIADIAZINE DERIVATIVE S-18986, A NEW AMPA RECEPTOR-POSITIVE MODULATOR
Autore:
DESOS P; SERKIZ B; MORAIN P; LEPAGNOL J; CORDI A;
Indirizzi:
INST RECH SERVIER,11 RUE MOULINEAUX F-92150 SURESNES FRANCE INST RECH SERVIER F-92150 SURESNES FRANCE
Titolo Testata:
Bioorganic & medicinal chemistry letters
fascicolo: 24, volume: 6, anno: 1996,
pagine: 3003 - 3008
SICI:
0960-894X(1996)6:24<3003:ESOAPD>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
LITHIUM ALUMINUM-HYDRIDE; ASYMMETRIC REDUCTION; KETONES; DESENSITIZATION; CYCLOTHIAZIDE; REAGENTS; POTENTIATION; S,S-DIOXIDE; COGNITION; MEMORY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
P. Desos et al., "ENANTIOSELECTIVE SYNTHESIS OF A PYRROLO-BENZOTHIADIAZINE DERIVATIVE S-18986, A NEW AMPA RECEPTOR-POSITIVE MODULATOR", Bioorganic & medicinal chemistry letters, 6(24), 1996, pp. 3003-3008

Abstract

Enantioselective reduction of pyrrolo-benzothiadiazine 6 using various chiral reducing agents has been studied and led to efficient synthesis of 8 (S 18986) which was established to be of (S) configuration by single crystal X-ray diffraction analysis. S 18986 is a potent and selective AMPA positive modulator which displays total stereoselectivity,the (R) enantiomer being completely inactive. Copyright (C) 1996 Elsevier Science Ltd

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/08/20 alle ore 23:09:56