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Titolo:
FACTORS RESPONSIBLE FOR MULTIPLE PREGNANCIES AFTER OVARIAN STIMULATION AND INTRAUTERINE INSEMINATION WITH GONADOTROPINS
Autore:
VALBUENA D; SIMON C; ROMERO JL; REMOHI J; PELLICER A;
Indirizzi:
INST VALENCIANO INFERTIL,GUARDIA CIVIL 23 VALENCIA 46020 SPAIN INST VALENCIANO INFERTIL VALENCIA 46020 SPAIN
Titolo Testata:
Journal of assisted reproduction and genetics
fascicolo: 8, volume: 13, anno: 1996,
pagine: 663 - 668
SICI:
1058-0468(1996)13:8<663:FRFMPA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRIPLET PREGNANCIES; EMBRYO REDUCTION; INFERTILITY; NUMBERS; CYCLES;
Keywords:
ARTIFICIAL INSEMINATION; MULTIPLE PREGNANCY; SUPEROVULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
D. Valbuena et al., "FACTORS RESPONSIBLE FOR MULTIPLE PREGNANCIES AFTER OVARIAN STIMULATION AND INTRAUTERINE INSEMINATION WITH GONADOTROPINS", Journal of assisted reproduction and genetics, 13(8), 1996, pp. 663-668

Abstract

Purpose: The present study was undertaken in order to analyze possible factors that could be responsible for multiple pregnancies in normoovulatory women undergoing superovulation with gonadotropins and intrauterine artificial insemination. Methods: We retrospectively analyzed several clinical parameters in patients that achieved gestation with this treatment. Patients were divided into two groups depending on spermorigin (husband and donor sperm), Furthermore, they were subclassified as follows: (a) cycles resulting in single pregnancies (n = 366), (b) cycles ending in multiple pregnancies (n = 126), and (c) a control group composed of unsuccessful cycles (n = 366). Results: In cycles employing husband's sperm, the age, number of cycles necessary to reach pregnancy, serum estradiol (E(2)) levels, and number of follicles were significantly (P < 0.05) different in multiple pregnancies compared tosingle or nonpregnant cycles. In donor insemination, women with multiple pregnancies were significantly younger than nonpregnant patients. There was a significant increase in the number of follicles developed (P < 0.00001) and serum E(2) levels on the day of hCG (P < 0.05) in multiple compared to single pregnancies and unsuccessful cycles. The number of motile sperm in the insemination specimen was not different among the established groups. When both types of treatments were grouped pregnant patients were significantly (P < 0.00001) younger than women with failed cycles. In addition, multifetal pregnancies were significantly (P < 0.05) more frequent in women <30 years old. E(2) production was significantly (P < 0.00008) higher in twin and multifetal pregnancies than in single or nonpregnant cycles. Follicular development was also significantly (P < 0.00001) higher in twin and multifetal pregnancies compared to failed cycles. Conclusions: The results suggest that young women (<30 years) who develop more than six follicles with E(2) >1000 pg/ml when stimulated with gonadotropins are at higher risk of multiple gestation. These data may be helpful in preventing this undesired complication of assisted reproduction techniques.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:32:36