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Titolo:
SCREENING FOR WILMS-TUMOR IN CHILDREN WITH HIGH-RISK CONGENITAL SYNDROMES - CONSIDERATIONS FOR AN INTERVENTION TRIAL
Autore:
DEBAUN MR; BROWN M; KESSLER L;
Indirizzi:
NCI,GENET EPIDEMIOL BRANCH,NIH,EPN 439,6130 EXECUT BLVD ROCKVILLE MD 20892 NCI,APPL RES BRANCH,NIH ROCKVILLE MD 20892
Titolo Testata:
Medical and pediatric oncology
fascicolo: 5, volume: 27, anno: 1996,
pagine: 415 - 421
SICI:
0098-1532(1996)27:5<415:SFWICW>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
BECKWITH-WIEDEMANN SYNDROME; COST-EFFECTIVENESS; BREAST-CANCER; HEMIHYPERTROPHY; MANAGEMENT; ANIRIDIA; PATIENT; DESIGN;
Keywords:
CANCER SCREENING; WILMS TUMOR; INTERVENTION TRIAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
M.R. Debaun et al., "SCREENING FOR WILMS-TUMOR IN CHILDREN WITH HIGH-RISK CONGENITAL SYNDROMES - CONSIDERATIONS FOR AN INTERVENTION TRIAL", Medical and pediatric oncology, 27(5), 1996, pp. 415-421

Abstract

Screening for cancer in children is uncommon. However, in children with congenital syndromes associated with Wilms' tumor, conditions existthat potentially make screening effective. This select population of children 1) are relatively easily identified; 2) have a high incidenceof Wilms' tumor; 3) if identified before development of Wilms' tumor,may have a decrement in morbidity/mortality; and 4) are amenable to asimple and acceptable screening technology, renal sonography exams. Many clinicians have recommended screening for cancer in children with congenital syndromes associated with Wilms' tumor. However, neither costs nor effectiveness of such recommendations have been evaluated systematically. The strongest evidence for or against Wilms' tumor screening in this select population would be provided by a randomized screening trial. Prior to undertaking such a trial, the key parameters that dominate the cost and effectiveness of screening should be identified. Simulation models, such as cost-effectiveness analysis, offer a starting point for deciding whether cancer screening is appropriate, and ii so, under what set of conditions. We review basic conditions required for a successful screening trial in children with syndromes that are at increased risk of Wilms' tumor. We also discuss the use of cost-effectiveness analysis as a preliminary step in determining the feasibility of an intervention trial. (C) 1996 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:29:44