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Titolo:
ASSESSMENT OF CEREBRAL BLOOD-FLOW RESERVE USING FUNCTIONAL MAGNETIC-RESONANCE-IMAGING
Autore:
HEDERA P; LAI S; LEWIN JS; HAACKE EM; WU D; LERNER AJ; FRIEDLAND RP;
Indirizzi:
UNIV HOSP CLEVELAND,DEPT NEUROL,ALZHEIMER CTR,11100 EUCLID AVE CLEVELAND OH 44106 UNIV HOSP CLEVELAND,DEPT NEUROL,ALZHEIMER CTR CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,DEPT PHYS CLEVELAND OH 44106 UNIV HOSP CLEVELAND,DEPT RADIOL CLEVELAND OH 44106 ST LUKES HOSP,DEPT MED CLEVELAND OH 00000
Titolo Testata:
Journal of magnetic resonance imaging
fascicolo: 5, volume: 6, anno: 1996,
pagine: 718 - 725
SICI:
1053-1807(1996)6:5<718:AOCBRU>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSORY STIMULATION; ACETAZOLAMIDE; ACTIVATION; PERFUSION; CORTEX; MRI; OXYGENATION; CONTRAST; DISEASE;
Keywords:
FUNCTIONAL MAGNETIC RESONANCE IMAGING; ACETAZOLAMIDE; VASOREACTIVITY; CEREBRAL BLOOD FLOW; DEOXYHEMOGLOBIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
P. Hedera et al., "ASSESSMENT OF CEREBRAL BLOOD-FLOW RESERVE USING FUNCTIONAL MAGNETIC-RESONANCE-IMAGING", Journal of magnetic resonance imaging, 6(5), 1996, pp. 718-725

Abstract

Imaging of activated brain areas based on changes of blood deoxyhemoglobin levels is now possible with MRI. Acetazolamide (ACZ) increases cerebral blood now (CBF) without changing cerebral oxygen consumption; this results in signal changes observed in gradient echo MR images from the areas with an increase in CBF, We assessed signal changes after ACZ application in seven healthy subjects with a conventional 1.5-T MRI scanner. The susceptibility-sensitized three-dimensional fast low-angle shot (FLASH) sequence was used to visualize signal changes inducedby ACZ. We analyzed anatomic localization of different ranges of detected signal changes. ACZ caused significant signal changes in the graymatter and at the edge of the cerebral cortex, the latter corresponding to draining surface veins. No significant differences were seen among different brain areas within the same slice. Using the maximum intensity projection technique, we were able to partially separate signal changes originating in draining veins from signal originating in the gray matter microvasculature. Signal changes from the microvessels reflect cerebrovascular reserve, Blood-oxygen-level-dependent (BOLD) basedMRI can evaluate CBF reserve with high spatial and temporal resolution, To assess cerebrovascular reserve, it is necessary to separate signal changes originating in large vessels from signal from brain microvasculature.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 07:22:04