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Titolo:
A DISTRIBUTION STUDY OF C-11 PLATELET-ACTIVATING-FACTOR (PAF) ANALOGSIN NORMAL AND TUMOR-BEARING MICE
Autore:
SASAKI T; TOHYAMA T; ODA K; TOYAMA H; ISHII SI; SENDA M; KARASAWA K; SATOH N; SETAKA M; NOJIMA S; NOZAKI T; BRAQUET P;
Indirizzi:
TOKYO METROPOLITAN INST GERONTOL,POSITRON MED CTR,1-1 NAKA CHO TOKYO 173 JAPAN TEIKYO UNIV,FAC PHARMACEUT SCI KANAGAWA JAPAN KITASATO UNIV,FAC HYG SCI KANAGAWA JAPAN INST HENRI BEAUFOUR,RES LABS F-92350 LE PLESSIS ROBINS FRANCE
Titolo Testata:
Nuclear medicine and biology
fascicolo: 3, volume: 23, anno: 1996,
pagine: 309 - 314
SICI:
0969-8051(1996)23:3<309:ADSOCP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR ACETYLHYDROLASE; INTERLEUKIN-1 IL1; FACTOR RECEPTOR; HUMAN-PLASMA; ANTAGONIST; RAT; EXPRESSION; ACETHER; INVITRO; INVIVO;
Keywords:
PLATELET-ACTIVATING FACTOR RECEPTORS; SN-GLYCERO-3-PHOSPHOCHOLINE[CHOLINE-METHYL-[C-11]]; ENANTIOMER; SPLEEN; TUMOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
T. Sasaki et al., "A DISTRIBUTION STUDY OF C-11 PLATELET-ACTIVATING-FACTOR (PAF) ANALOGSIN NORMAL AND TUMOR-BEARING MICE", Nuclear medicine and biology, 23(3), 1996, pp. 309-314

Abstract

As a preliminary study to image platelet activating factor (PAF) receptors in vivo, com parative study of biodistribution between -hexadecyl-2-O-N,N-dimethylcarbamoyl-sn-glycero-3- holine-methyl-C-11](L-[C-11]dimethylcarbamoyl-PAF) and nonspecific PAF analog, -hexadecyl-2-O-N,N-dimethylcarbamoyl-sn-glycero-1- phosphocholine[choline-methyl-C-11](D-[C-11]- dimethylcarbamoyl-PAF) was carried out in both normal and tumor bearing mice. Higher accumulation of L-[C-11]dimethylcarbamoyl-PAF than D-[C-11]dimethylcarbamoyl-PAF was observed in normal mice spleen. The co administration of PAF antagonists dose dependently reduced the radioactivity level of the L-isomer only in the spleen, In mice bearing Ehrlich tumors and Sarcoma 180, more L- than the D-[C-11]-isomer wasaccumulated in the tumor and spleen. We found that specific accumulation sites for L-[C-11]dimethylcarbamoyl-PAF exist in the spleen and tumors than in other tissues. Moreover, the comparison of accumulation between L- and D-[C-11]dimethylcarbamoyl-PAF would be a useful procedure for estimation of PAF receptors in vivo.

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Documento generato il 27/11/20 alle ore 02:24:12