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Titolo:
SPECIFIC BINDING-COMPONENT OF THE INACTIVE STEREOISOMER (S,S)-[I-125]IQNB TO RAT-BRAIN MUSCARINIC RECEPTORS IN-VIVO
Autore:
BOULAY SF; MCREE RC; COHEN VI; SOOD VK; ZEEBERG BR; REBA RC;
Indirizzi:
GEORGE WASHINGTON UNIV,MED CTR,DEPT RADIOL,SECT RADIOPHARMACEUT CHEM,ROOM 662,ROSS HALL WASHINGTON DC 20037 GEORGE WASHINGTON UNIV,MED CTR,DEPT RADIOL,SECT RADIOPHARMACEUT CHEM WASHINGTON DC 20037 UNIV CHICAGO HOSP & CLIN,DEPT RADIOL,NUCL MED SECT CHICAGO IL 60637
Titolo Testata:
Nuclear medicine and biology
fascicolo: 3, volume: 23, anno: 1996,
pagine: 211 - 219
SICI:
0969-8051(1996)23:3<211:SBOTIS>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
OPIATE ANTAGONIST CYCLOFOXY; KINETIC-ANALYSIS; 3-QUINUCLIDINYL 4-IODOBENZILATE; INVIVO; INVITRO; ENANTIOMERS; TRANSPORT; SUBTYPES;
Keywords:
PHARMACOKINETIC MODELING; EMISSION TOMOGRAPHIC NEURORECEPTOR QUANTITATION; RADIOIODINATED (R,S)-4IQNB; RADIOIODINATED (S,S)-4IQNB;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
S.F. Boulay et al., "SPECIFIC BINDING-COMPONENT OF THE INACTIVE STEREOISOMER (S,S)-[I-125]IQNB TO RAT-BRAIN MUSCARINIC RECEPTORS IN-VIVO", Nuclear medicine and biology, 23(3), 1996, pp. 211-219

Abstract

In vivo nonspecific binding can be estimated using the inactive stereoisomer of a receptor radioligand. However, the binding of the inactive stereoisomer may be partially specific. Specific binding of the inactive (S,S)-[I-125]IQNB was estimated from the inhibition induced by a competing nonradioactive ligand. This technique differed from the usual approach, since it was used to study the inactive rather than the active stereoisomer. The results indicate that there is substantial specific binding for (S,S)-[I-125]IQNB.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 20:11:13