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Titolo:
CHARACTERIZATION OF THE GENETIC-POLYMORPHISM OF DIHYDROCODEINE O-DEMETHYLATION IN MAN VIA ANALYSIS OF URINARY DIHYDROCODEINE AND DIHYDROMORPHINE BY MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY
Autore:
HUFSCHMID E; THEURILLAT R; WILDERSMITH CH; THORMANN W;
Indirizzi:
UNIV BERN,DEPT CLIN PHARMACOL,MURTENSTR 35 CH-3010 BERN SWITZERLAND UNIV BERN,DEPT CLIN PHARMACOL CH-3010 BERN SWITZERLAND KLIN BEAU SITE BERN SWITZERLAND
Titolo Testata:
Journal of chromatography B. Biomedical applications
fascicolo: 1, volume: 678, anno: 1996,
pagine: 43 - 51
Fonte:
ISI
Lingua:
ENG
Soggetto:
POOR METABOLIZERS; DEBRISOQUINE HYDROXYLATION; THERAPEUTIC IMPLICATIONS; EXTENSIVE METABOLIZERS; CODEINE; OXIDATION; PHENOTYPE; CAFFEINE; PHARMACOKINETICS; ELECTROPHORESIS;
Keywords:
DIHYDROCODEINE; DIHYDROMORPHINE; DEBRISOQUINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
E. Hufschmid et al., "CHARACTERIZATION OF THE GENETIC-POLYMORPHISM OF DIHYDROCODEINE O-DEMETHYLATION IN MAN VIA ANALYSIS OF URINARY DIHYDROCODEINE AND DIHYDROMORPHINE BY MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY", Journal of chromatography B. Biomedical applications, 678(1), 1996, pp. 43-51

Abstract

The genetic polymorphism of dihydrocodeine O-demethylation in man viaanalysis of urinary dihydrocodeine (DHC) and dihydromorphine (DHM) bymicellar electrokinetic capillary chromatography is described. Ten healthy subjects which are known to be extensive metabolizers for debrisoquine ingested 60 mg of DHC and collected their 0-12 h urines. In these samples, about 1% of the administered DHC equivalents are shown to be excreted as DHM. Premedication of 50 mg quinidine sulfate to the same subjects is demonstrated to significantly reduce (3-4 fold) the amount of O-demethylation of DHC, a metabolic step which is thereby demonstrated to co-segregate with the hydroxylation of debrisoquine. Thus, in analogy to codeine and other substrates, extensive and poor metabolizer phenotypes for DHC can be distinguished. Using the urinary DHC/DHM metabolic ratio to characterize the extent of O-demethylation, the metabolic ratio ranges of extensive and poor metabolizers in a frequency histogram are shown to partially overlap. Thus, classification of borderline values is not unequivocal and DHC should therefore not be employed for routine pharmacogenetic screening purposes. Nevertheless, the method is valuable for metabolic research and preliminary data demonstrate that the same assay could also be used to explore the metabolism of codeine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:14:06