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Titolo:
MORPHOLOGICAL ALTERATIONS IN THE HIPPOCAMPUS FOLLOWING HYPOBARIC HYPOXIA
Autore:
SHUKITTHALE B; KADAR T; MARLOWE BE; STILLMAN MJ; GALLI RL; LEVY A; DEVINE JA; LIEBERMAN HR;
Indirizzi:
USA,ENVIRONM MED RES INST,MIL PERFORMANCE & NEUROSCI DIV NATICK MA 01760 USA,ENVIRONM MED RES INST,MIL PERFORMANCE & NEUROSCI DIV NATICK MA 01760 GEOCENTERS INC NEWTON MA 02159 ISRAEL INST BIOL RES,DEPT PHARMACOL IL-70450 NESS ZIONA ISRAEL
Titolo Testata:
Human & experimental toxicology
fascicolo: 4, volume: 15, anno: 1996,
pagine: 312 - 319
SICI:
0960-3271(1996)15:4<312:MAITHF>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; RAT HIPPOCAMPUS; ALTITUDE; ISCHEMIA; DYSFUNCTION; EXPOSURE; OXYGEN;
Keywords:
HYPOBARIC HYPOXIA; CHRONIC ALTITUDE EXPOSURE; HIPPOCAMPUS; DELAYED NEUROTOXICITY; ISCHEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
B. Shukitthale et al., "MORPHOLOGICAL ALTERATIONS IN THE HIPPOCAMPUS FOLLOWING HYPOBARIC HYPOXIA", Human & experimental toxicology, 15(4), 1996, pp. 312-319

Abstract

1 The morphological consequences of hypobaric hypoxia, exposure to reduced pressure atmospheres, were examined in the hippocampus of male Fischer 344 rats. Severe chronic hypoxia can produce permanent neuronaldamage with hippocampal structures being especially vulnerable. 2 Hippocampal morphology was studied using histological observations after a 4 day exposure to sea level, 5500 m, or 6400 m. Two groups tested at6400 m were sacrificed at different intervals following exposure, 72 and 144 h, to examine the effect of post-exposure time on neuronal damage. 3 Histological damage was observed in rats' brains following exposure to altitude, with cell degeneration and death increasing as altitude increased. In addition, it was found that the longer the time following exposure before sacrifice, the more noticeable the damage, suggesting delayed neurotoxicity. Increases in the number of damaged cells following altitude were significant for the CA3 region of one 6400 m group; however, other differences did not reach statistical significance. Rats exposed to altitude for 4 days ate less and lost significantlymore weight than did animals at sea level. 4 It appears that 4 days of exposure to altitudes less than or equal to 6400 m does produce changes in the CA3 subfield, but the damage is different than that seen with other models of non-transient ischemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:51:25