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Titolo:
GENOTOXICITY OF ALOEEMODIN IN-VITRO AND IN-VIVO
Autore:
HEIDEMANN A; VOLKNER W; MENGS U;
Indirizzi:
MADAUS AG,ABT TOXIKOL,OSTMERHEIMER STR 198 D-51109 COLOGNE GERMANY MADAUS AG,ABT TOXIKOL D-51109 COLOGNE GERMANY CYTOTEST CELL RES D-64380 ROSSDORF GERMANY SCI CONSULTING CO D-55546 BIEBELSHEIM GERMANY
Titolo Testata:
Mutation research. Genetic toxicology testing
fascicolo: 3, volume: 367, anno: 1996,
pagine: 123 - 133
SICI:
0165-1218(1996)367:3<123:GOAIAI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-TOX PROGRAM; CHRYSAZIN; INVIVO; LIVER; MICE; RATS;
Keywords:
ANTHRAQUINONE; ALOEEMODIN; GENOTOXICITY; IN VITRO; IN VIVO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
A. Heidemann et al., "GENOTOXICITY OF ALOEEMODIN IN-VITRO AND IN-VIVO", Mutation research. Genetic toxicology testing, 367(3), 1996, pp. 123-133

Abstract

The present in vitro and in vivo experiments were undertaken to clarify the genotoxic potential of the hydroxyanthrachinone aloeemodin which can be found in different plant derived products for therapy of constipation. The results demonstrate that aloeemodin is able to induce mutagenic effects in vitro. Positive results were obtained in the chromosomal aberration assay with CHO cells, as well as in the Salmonella reverse mutation assay (frameshift mutations in strains TA 1537, TA 1538and TA 98). No mutagenic potential of aloeemodin, however, was observed in the gene mutation assay with mammalian cells in vitro (HPRT assay in V79 cells). Each assay was performed in the presence and absence of an extrinsic metabolic activation system (S9-mix). In in vivo studies (micronucleus assay in bone marrow cells of NMRI mice; chromosome aberration assay in bone marrow cells of Wistar rats; mouse spot test [DBA/2J x NMRI]) no indication of a mutagenic activity of aloeemodin was found. Information about a possible reaction of aloeemodin with DNA was derived from an in vivo UDS assay. Hepatocytes of aloeemodin-treated male Wistar rats did not show DNA damage via repair synthesis. All these data suggest that aloeemodin is able to interact with DNA under certain in vitro conditions. However, in vivo the results that were negative did not indicate a genotoxic potential. Therefore, it may be assumed that a genotoxic risk for man might be unlikely.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:43:16