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Titolo:
ENDOTHELIN-1 PRODUCES HETEROGENEOUS REGIONAL HEMODYNAMIC-EFFECTS IN CONSCIOUS RABBITS
Autore:
ROBERTSTHOMSON P; MCRITCHIE RJ; CHALMERS JP;
Indirizzi:
FLINDERS MED CTR,DEPT MED BEDFORD PK SA 5042 AUSTRALIA FLINDERS MED CTR,DEPT MED BEDFORD PK SA 5042 AUSTRALIA FLINDERS MED CTR,CTR NEUROSCI BEDFORD PK SA 5042 AUSTRALIA
Titolo Testata:
Clinical and experimental hypertension
fascicolo: 2, volume: 18, anno: 1996,
pagine: 145 - 169
SICI:
1064-1963(1996)18:2<145:EPHRHI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE FORMATION; HEMODYNAMIC-RESPONSES; L-ARGININE; MYOCARDIAL-CONTRACTILITY; VASOCONSTRICTOR PEPTIDE; MESENTERIC-ARTERIES; VASODILATOR ACTION; CORONARY-ARTERIES; SARAFOTOXIN S6B; NEUROPEPTIDE-Y;
Keywords:
ARTERIAL BLOOD PRESSURE; CONSCIOUS RABBIT; ENDOTHELIN; HEMODYNAMICS; HEART RATE; HINDLIMB BLOOD FLOW; MESENTERIC BLOOD FLOW; RENAL BLOOD FLOW;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
P. Robertsthomson et al., "ENDOTHELIN-1 PRODUCES HETEROGENEOUS REGIONAL HEMODYNAMIC-EFFECTS IN CONSCIOUS RABBITS", Clinical and experimental hypertension, 18(2), 1996, pp. 145-169

Abstract

Blood flow in the renal artery, superior mesenteric artery and infra-renal abdominal aorta of conscious rabbits was measured by Doppler ultrasound. Arterial pressure, heart rate and blood flow responses were assessed following 0.2 and 0.8 nmol/kg intravenous endothelin-1. The effects of the following antagonists on these responses were examined: phentolamine, propranolol, scopolamine, captopril, nifedipine, indomethacin, the V-1-vasopressin receptor antagonist d(CH2)(5)Tyr(Me)AVP and the competitive nitric oxide (NO) synthase inhibitor N-G-nitro L-arginine (NOLA). Hindlimb resistance and arterial pressure responded in twophases, initial vasodilatation followed by vasoconstriction. Renal and mesenteric vasoconstriction occurred without initial vasodilatation. Following 0.2 nmol/kg endothelin-1, arterial pressure decreased by 18.5 +/- 0.8 mmHg, then increased by 25.2 +/- 1.7 mmHg (n = 27). Heart rate changed reciprocally. Renal resistance increased by 533 +/- 73% (n= 12). Mesenteric resistance increased by 420 +/- 34%. Hindlimb resistance decreased 54 +/- 2% (n = 12, all P < 0.01) then increased slightly (P < 0.05). All changes were greater at 0.8 nmol/kg, particularly the hindlimb vasoconstriction, The only antagonist to alter significantly these responses was NOLA, which in the hindlimb attenuated the vasodilatation and accentuated the vasoconstriction. We conclude that mostof the haemodynamic effects of endothelin-1 are direct, but that NO generated by NO synthase causes part of the hindlimb vasodilatation. and that endothelin-1-induced vasoconstriction is attenuated by release of NO.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 23:12:47