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Titolo:
AN ELECTRICAL NETWORK MODEL OF INTRACRANIAL ARTERIOVENOUS-MALFORMATIONS - ANALYSIS OF VARIATIONS IN HEMODYNAMIC AND BIOPHYSICAL PARAMETERS
Autore:
HADEMENOS GJ; MASSOUD TF;
Indirizzi:
UNIV CALIF LOS ANGELES,SCH MED,DEPT RADIOL SCI,ENDOVASC THERAPY SERV,10833 LE CONTE AVE LOS ANGELES CA 90024
Titolo Testata:
Neurological research
fascicolo: 6, volume: 18, anno: 1996,
pagine: 575 - 589
SICI:
0161-6412(1996)18:6<575:AENMOI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL HEMODYNAMICS; HEMORRHAGE; EMBOLIZATION; RADIOSURGERY; PRESSURE; AVMS; FLOW;
Keywords:
CEREBRAL ARTERIOVENOUS MALFORMATION; HEMODYNAMICS; MODELS, THEORETICAL; INTRACEREBRAL HEMORRHAGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
G.J. Hademenos e T.F. Massoud, "AN ELECTRICAL NETWORK MODEL OF INTRACRANIAL ARTERIOVENOUS-MALFORMATIONS - ANALYSIS OF VARIATIONS IN HEMODYNAMIC AND BIOPHYSICAL PARAMETERS", Neurological research, 18(6), 1996, pp. 575-589

Abstract

The propensity of intracranial arteriovenous malformations (AVMs) to hemorrhage is correlated significantly with their hemodynamic features. Biomathematical models offer a theoretical approach to analyse complex AVM hemodynamics, which otherwise are difficult to quantify, particularly within or in close proximity to the nidus. Our purpose was to investigate a newly developed biomathematical AVM model based on electrical network analysis in which morphological, biophysical, and hemodynamic characteristics of intracranial AVMs were replicated accurately. Several factors implemented into the model were altered systematicallyto study the effects of a possible wide range of normal variations inAVM hemodynamic and biophysical parameters on the behavior of this model and its fidelity to physiological reality. The model represented acomplex, noncompartmentalized AVM with four arterial feeders, two draining veins, and a nidus consisting of 28 interconnected plexiform andfistulous components. Various clinically-determined, experimentally-observed, or hypothetically-assumed values for the nidus vessel radii (plexiform: 0.01 cm-0.1 cm; fistulous: 0.1 cm-0.2 cm), mean systemic arterial pressure (71 mm Hg-125 mm Hg) mean arterial feeder pressures (21 mm Hg-80 mm Hg), mean draining vein pressures 15 mm Hg-23 mm Hg), wall thickness of nidus vessels (20 mu m-70 mu m), and elastic modulus of nidus vessels (1 x 10(4) dyn/cm(2) to 1 x 10(5) dyn/cm(2)) were usedas normal or realistic ranges of parameters implemented in the model. Using an electrical analogy of Ohm's law, flow was determined based on Poiseuille's law given the aforementioned pressures and resistance of each nidus vessel. Circuit analysis of the AVM vasculature based on the conservation of flow and voltage revealed the flow rate through each vessel in the AVM network. An expression for the risk of AVM nidus rupture was derived based on the functional distribution of the critical radii of component vessels. The two characteristics which were usedto judge the fidelity of the theoretical performance of the AVM modelagainst the physiological one of human AVMs were total volumetric flow through the AVM (less than or equal to 900 ml/min), and its risk of rupture (< 100%). Applying these criteria, a series of 216 (out of 260) AVM models using different combinations of these hemodynamic and biophysical parameters resulted in a physiologically-realistic conduct ofthe model (yielding a total flow through the AVM model varying from 449.9 ml/min to 888.6 ml/min, and a maximum risk of rupture varying from 26.4 to 99.9%). The described novel biomathematical model characterizes the transnidal and intranidal hemodynamics of an intracranial AVM more accurately than previously possible. A wide range of hemodynamic and biophysical parameters can be implemented in this AVM model to result in simulation of human AVMs with differing characteristics (e.g. low-flow and high-now AVMs). This experimental model should serve as a useful research tool for further theoretical investigations of a variety of intracranial AVMs and their hemodynamic sequelae.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 07:02:23