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Titolo:
THE CORTICOSTRIATAL PROJECTION - FROM SYNAPTIC PLASTICITY TO DYSFUNCTIONS OF THE BASAL GANGLIA
Autore:
CALABRESI P; PISANI A; MERCURI NB; BERNARDI G;
Indirizzi:
UNIV ROMA TOR VERGATA,NEUROL CLIN,DIP SANITA,VIA O RAIMONDO I-00173 ROME ITALY IRCCS,CLIN S LUCIA ROME ITALY
Titolo Testata:
Trends in neurosciences
fascicolo: 1, volume: 19, anno: 1996,
pagine: 19 - 24
SICI:
0166-2236(1996)19:1<19:TCP-FS>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; RECEPTOR MESSENGER-RNA; RAT STRIATAL NEURONS; HUNTINGTONS-DISEASE; DOPAMINE-D2 RECEPTOR; GLUTAMATE RECEPTORS; DEPRESSION; BRAIN; EXCITATION; ELECTROPHYSIOLOGY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
P. Calabresi et al., "THE CORTICOSTRIATAL PROJECTION - FROM SYNAPTIC PLASTICITY TO DYSFUNCTIONS OF THE BASAL GANGLIA", Trends in neurosciences, 19(1), 1996, pp. 19-24

Abstract

Corticostriatal transmission has an important function in the regulation of the neuronal activity of the basal ganglia. The firing activityof corticostriatal neurones excites striatal cells via the release ofglutamate. Presynaptic receptors that ave located on corticostriatal terminals and that regulate the release of glutamate in the striatum have been postulated for dopamine and glutamate. Activation of these receptors may exert a negative feed-back on the striatal release of glutamate. High-frequency activation of corticostriatal fibres causes either long-term depression or long-term potentiation of excitatory transmission depending on the subclass of glutamate receptor that is activated. These forms of synaptic plasticity could be involved in motor learning. Alterations in striatal synaptic plasticity might be implicated in Parkinson's disease and Huntington's disease.

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Documento generato il 20/09/20 alle ore 20:17:55