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Titolo:
SYNTHESIS, STRUCTURE AND ANTITUMOR-ACTIVITY OF NEW BENZ[D,E]ISOQUINOLINE-1,3-DIONES
Autore:
BRANA MF; CASTELLANO JM; MORAN M; EMLING F; KLUGE M; SCHLICK E; KLEBE G; WALKER N;
Indirizzi:
LABS KNOLL SA,AVDA BURGOS 91 E-28050 MADRID SPAIN KNOLL SA MADRID SPAIN KNOLL AG W-6700 LUDWIGSHAFEN GERMANY BASF AG,HAUPTLAB W-6700 LUDWIGSHAFEN GERMANY
Titolo Testata:
Arzneimittel-Forschung
fascicolo: 12, volume: 45-2, anno: 1995,
pagine: 1311 - 1318
SICI:
0004-4172(1995)45-2:12<1311:SSAAON>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA; AMONAFIDE; ACID; BINDING; DRUGS;
Keywords:
AMONAFIDE; ANTITUMOR AGENTS; BENZ[D,E]ISOQUINOLINE-1,3-DIONES, IN VITRO AND IN VIVO STUDIES SYNTHESIS; CAS 54824-17-8; CAS 69408-81-7; MITONAFIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
M.F. Brana et al., "SYNTHESIS, STRUCTURE AND ANTITUMOR-ACTIVITY OF NEW BENZ[D,E]ISOQUINOLINE-1,3-DIONES", Arzneimittel-Forschung, 45-2(12), 1995, pp. 1311-1318

Abstract

New benz[d, e]isoguinoline-1,3-diones related to mitonafide (GAS 54824-17-8) and amonafide (CAS 69408-81-7) with double substitution on thechromaphore and branched side chains have been synthesized and their biological activity determined Molecular modeling studies of 3a based on X-ray crystallographic data of mitonafide have shown that the aromatic system intercalates between GC steps of DNA. The in vitro cytotoxic test data using CX-1 and LX-1 cells showed higher cytotoxic activities in disubstituted derivatives compared to both lead compounds. Some of the compounds have been selected for in vivo rest using L1210 tumorcells and CX-I cells Two of them (3b and 3j) have shown promising activity as good candidates for clinical development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 23:01:16