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Titolo:
PSYCHOPHARMACOLOGY OF CENTRAL SEROTONERGIC SYSTEMS
Autore:
BAUMGARTEN HG; GROZDANOVIC Z;
Indirizzi:
FREE UNIV BERLIN,INST ANAT,DEPT ANAT,KONIGIN LUISE STR 15 D-14195 BERLIN GERMANY
Titolo Testata:
Pharmacopsychiatry
, volume: 28, anno: 1995, supplemento:, 2
pagine: 73 - 79
SICI:
0176-3679(1995)28:<73:POCSS>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN-SEROTONIN; RECEPTORS; NEURONS; 5-HT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
H.G. Baumgarten e Z. Grozdanovic, "PSYCHOPHARMACOLOGY OF CENTRAL SEROTONERGIC SYSTEMS", Pharmacopsychiatry, 28, 1995, pp. 73-79

Abstract

Serotonin neurons in the rostral and caudal brainstem raphe nuclear groups give rise to collateralized ascending and descending projectionswhich provide modulatory input into most networks throughout the entire neuraxis, The rostral raphe system is interconnected with target forebrain areas through reciprocal limbic-midbrain loops, which suggeststhat serotonin has a role in the regulation of complex intelligent adaptive behavior. Serotonergic pathways sensitize brainstem and spinal cord central rhythmic pattern generators which organize repetitive autonomic and motor activities, e.g, oral-buccal and nutritive behaviors,facilitate tonically active motor neurons innervating antigravity muscles, and disfacilitate somatosensory information processing. Serotonin effects are mediated by multiple receptor subtypes with distinct pre- and postsynaptic localization and regional distribution pattern. They belong to the G protein superfamily, coupling to adenylate cyclase (5-HT1,4,5,6,7) or phospholipase C (5-HT2), and to the ligand-gated ionchannel superfamily (5-HT3). Drugs acting at these receptors are known to modulate various aspects of cooperative social behavior and responding latency, i.e. impulsivity, in a variety of experimental models of anxiety and depression. The clinical efficacy of the so-called selective serotonin reuptake inhibitors (SSRIs) in disorders characterized by poor impulse control, e.g, bulimia nervosa, obsessive-compulsive disorder (OCD) and violent suicidal or homicidal behavior, may likewise be due to improved responding latency.

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Documento generato il 07/07/20 alle ore 14:53:58