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Titolo:
EXPRESSION OF GALACTOSYLTRANSFERASE IN PROSTATIC TUMORS
Autore:
AMSELGRUBER WM; SINOWATZ F; KOLLE S; LINCOLN DT; KAYSER K;
Indirizzi:
UNIV MUNICH,INST VET ANAT 2,VET STR 13 D-80935 MUNICH GERMANY FAC ALLIED HLTH SCI & NURSING SULAIBIKHAT SULIBIKHAT KUWAIT UNIV HEIDELBERG,DEPT PATHOL W-6900 HEIDELBERG GERMANY
Titolo Testata:
Nutrition
fascicolo: 5, volume: 11, anno: 1995, supplemento:, S
pagine: 638 - 642
SICI:
0899-9007(1995)11:5<638:EOGIPT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMBRYONAL CARCINOMA-CELLS; SURFACE GALACTOSYLTRANSFERASE; LAMININ RECEPTORS; ADHESION; METASTASIS; CANCER; BETA-1,4-GALACTOSYLTRANSFERASE; PROTEINS; BINDING;
Keywords:
PROSTATIC NEOPLASMS; TISSUE GALACTOSYLTRANSFERASES; IMMUNOCYTOCHEMISTRY; TUMOR MARKER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
W.M. Amselgruber et al., "EXPRESSION OF GALACTOSYLTRANSFERASE IN PROSTATIC TUMORS", Nutrition, 11(5), 1995, pp. 638-642

Abstract

Galactosyltransferase (GalTase) has been discovered on a variety of cells where it is believed to be involved in cell-cell adhesion and cell-substratum adhesion as well as in metastasis of carcinoma cells. This immunohistochemical study was undertaken to identify the topography and the cellular distribution of GalTase in normal prostatic tissue, benign prostatic hyperplasia (11 cases), and prostatic carcinoma (26 cases). Immunoreactive GalTase was found to be exclusively associated with carcinoma cells and with premalignant epithelial cells in prostatichyperplasia. In highly differentiated carcinomas, most of the carcinoma cells are positive for GalTase, whereas in poorly differentiated tumors, GalTase immunoreactivity was restricted to a subset of carcinomacells with obviously invasive behavior At the cellular level, GalTasewas localized in the cytoplasm and at the cell membrane. In sections of normal prostatic tissue, as well as in unaltered acini of prostatichyperplasic tissue, GalTase was not expressed. Fibroblasts, smooth muscle cells, and endothelial cells of the prostatic stroma were also consistently negative. With the use of immunoblots, we could confirm thepresence of GalTase with a molecular mass of 45 kDa in the extracts of benign prostatic hyperplasic tissue and in prostatic carcinoma tissue bur not in normal prostatic tissue. The results of our immunohistochemical study suggest that GalTase is a valuable marker to diagnose neoplastic transformation in prostatic tissue.

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Documento generato il 04/12/20 alle ore 00:39:44