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Titolo:
POTENTIAL USEFULNESS OF BIOTINYLATED NEOGLYCOPROTEINS AS TUMOR-MARKERS
Autore:
LINCOLN DT; TEMMIN L; ALJARALLAH MA; SINOWATZ F; GABIUS H; ELHIFNAWI ES; DASHTI H;
Indirizzi:
KUWAIT UNIV,FAC ALLIED HLTH SCI & NURSING,DEPT MED LAB TECHNOL,POB 31470 SULIBIKHAT KUWAIT UNIV MUNICH,INST VET ANAT W-8000 MUNICH GERMANY UNIV MUNICH,INST BIOCHEM W-8000 MUNICH GERMANY UNIV LUBECK,DEPT OPHTHALMOL W-2400 LUBECK GERMANY KUWAIT UNIV,FAC MED,DEPT SURG KUWAIT KUWAIT
Titolo Testata:
Nutrition
fascicolo: 5, volume: 11, anno: 1995, supplemento:, S
pagine: 632 - 637
SICI:
0899-9007(1995)11:5<632:PUOBNA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
GALACTOSIDE-BINDING LECTIN; HUMAN-BREAST; ENDOGENOUS LECTINS; GLYCOPROTEINS; CELLS; PROTEINS; GLYCOLIPIDS; CARCINOMAS; SURFACE; TISSUE;
Keywords:
NEOGLYCOPROTEINS; TUMOR MARKERS; TUMOR LINES; CELL CULTURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
D.T. Lincoln et al., "POTENTIAL USEFULNESS OF BIOTINYLATED NEOGLYCOPROTEINS AS TUMOR-MARKERS", Nutrition, 11(5), 1995, pp. 632-637

Abstract

We used several biotinylated neoglycoproteins as tumor markers to detect and localize endogenous carbohydrate-binding proteins in cultured hepatoblastoma, melanoma, and bladder carcinoma tumor cells. The neoglycoproteins used consisted of cellobiose, fucose, N-acetyl-gatactosamine, N-acetyl-glucosamine, lactose, maltose, mannose, melibiose, and xylose. In addition, naturally occurring asialofetuin that was chemically disialylated was also used. Binding to the cultured tumor cells was made visible with the avidin-peroxidase technique. Depending on the type of neoglycoprotein used, markedly different expression of cytoplasmic and nuclear receptors for sugars (endogenous lectins) was obtained from rat hepatoblastoma, human melanoma, and bladder carcinoma tumor cells. The most pronounced staining differences were documented for asialofetuin and the neoglycoproteins containing fucose, N-acetyl-galactosamine, and lactose.

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Documento generato il 04/12/20 alle ore 22:17:33