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Titolo:
GINSENOSIDES INCREASE SECRETION OF LIPOPROTEIN-LIPASE BY 3T3-L1 ADIPOCYTES
Autore:
MASUNO H; KITAO T; OKUDA H;
Indirizzi:
EHIME COLL HLTH SCI,DEPT MED LAB TECHNOL TOBE EHIME 79121 JAPAN EHIME COLL HLTH SCI,DEPT MED LAB TECHNOL TOBE EHIME 79121 JAPAN EHIME UNIV,SCH MED,DEPT MED BIOCHEM SHIGENOBU EHIME 79102 JAPAN
Titolo Testata:
Bioscience, biotechnology, and biochemistry
fascicolo: 12, volume: 60, anno: 1996,
pagine: 1962 - 1965
SICI:
0916-8451(1996)60:12<1962:GISOLB>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CULTURED BROWN ADIPOCYTES; EXPRESSION; GINSENG; GLUCOSE; MICE;
Keywords:
3T3-L1 ADIPOCYTES; GINSENOSIDE; LIPOPROTEIN LIPASE; SECRETION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
H. Masuno et al., "GINSENOSIDES INCREASE SECRETION OF LIPOPROTEIN-LIPASE BY 3T3-L1 ADIPOCYTES", Bioscience, biotechnology, and biochemistry, 60(12), 1996, pp. 1962-1965

Abstract

Treatment of 3T3-L1 adipocytes with either an oleanolic acid glycoside or a 20(S)-protopanaxatriol glycoside increased the secretion of lipoprotein lipase activity into the medium dose-dependently. At a concentration of 100 mu g/ml, ginsenosides Ro, Re, Rg(1), and Rh-1 increasedthe secretion of lipase activity into the medium ba 119, 107, 56, and32%, respectively, The ratio of lipase activity in the medium to cellular lipase activity was 4.7% in control cells and 8.6% in ginsenosideRe-treated cells, 8.30;:, in ginsenoside Re-treated cells. 7.0% in ginsenoside Rg(1)-treated cells, and 6.3% in ginsenoside Rh-1-treated cells, Ginsenoside Rb-2, which is a 20(S)-protopanaxadiol glycoside, increased the secretion of lipase activity by 16% at 25 mu g/ml, and the ratio of lipase activity in the medium to cellular lipase activity washigher in ginsenoside Rb-2-treated cells than in control cells, However, at 100 and 200 mu g/ml, ginsenoside Rb-2 decreased the secretion of lipase activity in parallel with cellular lipase activity, Ginsenoside Rd also decreased the secretion of lipase activity in the same dose-dependent manner, Thus, the effective dose for the secretion of lipoprotein lipase activity with ginsenosides varies with their aglycone structure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 04:54:03