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Titolo:
INTRAARTERIAL INFUSION OF UROKINASE FOR ACUTE, CRITICAL ISCHEMIA IN THE LOWER-LIMB
Autore:
HICKEN GJ; LOSSING AG; RUBIN B; ARO L; AMELI FM;
Indirizzi:
UNIV TORONTO,WELLESLEY HOSP,DIV VASC SURG,SUITE 212,EK JONES BLDG,160WELLESLEY ST E TORONTO ON M4Y 1J3 CANADA UNIV TORONTO,WELLESLEY HOSP,DIV VASC SURG TORONTO ON M4Y 1J3 CANADA
Titolo Testata:
Canadian journal of surgery
fascicolo: 6, volume: 38, anno: 1995,
pagine: 486 - 491
SICI:
0008-428X(1995)38:6<486:IIOUFA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
THROMBOLYTIC AGENTS; MANAGEMENT; THROMBOSIS; GRAFTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
G.J. Hicken et al., "INTRAARTERIAL INFUSION OF UROKINASE FOR ACUTE, CRITICAL ISCHEMIA IN THE LOWER-LIMB", CAN J SURG, 38(6), 1995, pp. 486-491

Abstract

OBJECTIVE: To assess the value of intra-arterial urokinase infusion in the management-of acute, critical ischemia of the lower limb. DESIGN: A prospective study. SETTING: A vascular surgery department within auniversity hospital. PATIENTS: Twenty-five consecutive patients with acute, critical ischemia of the lower limb, excluding those requiring immediate surgical intervention. Follow-up ranged from 1 to 18 months. INTERVENTION: Angiography followed by intra-arterial infusion of urokinase. MAIN OUTCOME MEASURES: Angiographic and clinical evidence of clot lysis and limb reperfusion, any surgical procedures required and final clinical outcome. RESULTS: Urokinase was technically successful inlysing clot in 19 patients: 7 required no further treatment; in 8 an underlying lesion was identified and repaired by either percutaneous angioplasty or surgery; in the remaining 4 patients, although the clot was lysed, the limbs remained ischemic and, since reconstruction was considered impossible, amputation was required. Two patients improved clinically with little angiographic evidence of clot lysis. A total of nine patients required amputation, seven of these as a ''primary'' procedure after urokinase infusion. There were four episodes of significant morbidity but no deaths. CONCLUSION: Urokinase has a place in the management of acute vascular occlusion of the lower limb, not only in treating the occlusion but, equally importantly, in facilitating identification of lesions that require surgical intervention.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 01:11:58