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Titolo:
STRATEGY FOR DISTINGUISHING A NEW DQB1 ALLELE (DQB1-ASTERISK-0611) FROM THE CLOSELY-RELATED DQB1-ASTERISK-0602 ALLELE VIA SEQUENCE-SPECIFICPCR OR DIRECT DNA-SEQUENCING
Autore:
WILLIAMS TM; BASSINGER S; MOEHLENKAMP C; WU J; MONTOYA GD; GRIFFITH BB; MCAULEY JD; GOLDMAN S; MAURER DH; TROUP GM;
Indirizzi:
UNIV NEW MEXICO,DEPT PATHOL,MOL DIAGNOST CORE LAB,ROOM 337-BRF ALBUQUERQUE NM 87131 BLOOD SYST CENT LAB SCOTTSDALE AZ 00000 UNIV CHICAGO,MED CTR,SECT PEDIAT HEMATOL ONCOL CHICAGO IL 60637 EMORY UNIV HOSP,DEPT PATHOL & LAB MED ATLANTA GA 30322
Titolo Testata:
Tissue antigens
fascicolo: 3, volume: 48, anno: 1996,
pagine: 143 - 147
SICI:
0001-2815(1996)48:3<143:SFDAND>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC BEADS; SOLID SUPPORT; AMPLIFICATION; HLA-DQB1; PRIMERS;
Keywords:
HLA-DQB1; DIRECT DNA SEQUENCING; SEQUENCE SPECIFIC PCR; BONE MARROW TRANSPLANTATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
T.M. Williams et al., "STRATEGY FOR DISTINGUISHING A NEW DQB1 ALLELE (DQB1-ASTERISK-0611) FROM THE CLOSELY-RELATED DQB1-ASTERISK-0602 ALLELE VIA SEQUENCE-SPECIFICPCR OR DIRECT DNA-SEQUENCING", Tissue antigens, 48(3), 1996, pp. 143-147

Abstract

A novel DQ6 allele (DQB10611) was identified via direct DNA sequencing in an African-American donor for bone marrow transplantation. The allele was not suspected on the basis of a sequence specific PCR assay which instead indicated the presence of DQB10602. DQB1*0602 and DQB1*0611 differ in exon 2 only at codon 9 resulting in a tyrosine substitution for phenylalanine. A modification of current DQB1 sequence specific PCR assays was devised which allows distinction between the closelyrelated DQB10602 and DQB1*0611 alleles. Preliminary allele frequencystudies suggest that DQB10611 is rare both in a non-African Americansample and in Americans of African descent carrying DR11, DQ6 haplotypes. The selection of various DQB10611 detection methods is discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 19:04:55