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Titolo:
DIFFERENTIAL EFFECT OF CDP-CHOLINE ON BRAIN CYTOSOLIC CHOLINE LEVELS IN YOUNGER AND OLDER SUBJECTS AS MEASURED BY PROTON MAGNETIC-RESONANCESPECTROSCOPY
Autore:
BABB SM; APPELMANS KE; RENSHAW PF; WURTMAN RJ; COHEN BM;
Indirizzi:
MCLEAN HOSP,BRAIN IMAGING CTR,115 MILL ST BELMONT MA 02178 HARVARD UNIV,SCH MED,CONSOLIDATED DEPT PSYCHIAT BOSTON MA 00000 MIT,DEPT BRAIN & COGNIT SCI CAMBRIDGE MA 02139
Titolo Testata:
Psychopharmacology
fascicolo: 2, volume: 127, anno: 1996,
pagine: 88 - 94
Fonte:
ISI
Lingua:
ENG
Soggetto:
BARRIER TRANSPORT; RAT-BRAIN; PHOSPHATIDYLCHOLINE BIOSYNTHESIS; H-1-NMR SPECTROSCOPY; CELL-MEMBRANES; ACETYLCHOLINE; METABOLISM; INCREASES; CYTIDINE; RELEASE;
Keywords:
5'-CYTIDINE DIPHOSPHATE CHOLINE; CHOLINE; PHOSPHATIDYLCHOLINE; CYTIDINE; AGING; BRAIN; MAGNETIC RESONANCE SPECTROSCOPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
S.M. Babb et al., "DIFFERENTIAL EFFECT OF CDP-CHOLINE ON BRAIN CYTOSOLIC CHOLINE LEVELS IN YOUNGER AND OLDER SUBJECTS AS MEASURED BY PROTON MAGNETIC-RESONANCESPECTROSCOPY", Psychopharmacology, 127(2), 1996, pp. 88-94

Abstract

Phosphatidylcholine (PtdCho), which is essential for membrane integrity and repair, is reduced in brain cell membranes with age. Evidence from both animal and in vitro studies indicates that cytidine 5' diphosphate choline (CDP-choline) can increase the synthesis of PtdCho; however, the effect of CDP-choline on brain choline metabolism has not previously been studied in human subjects. In this study, in vivo proton magnetic resonance spectroscopy (H-1-MRS) was used to measure brain levels of cytosolic, choline-containing compounds before and after single oral doses of CDP-choline. Three hours after dosing, plasma choline increased similarly in younger (mean age 25 years) and older subjects (mean age 59 years). However, while the choline resonance in brain increased by 18% on average in younger subjects, it decreased by almost 6% in older subjects (P = 0.028), These results may be explained by a previously observed decrease in brain choline uptake, but not cytidine uptake, in older Subjects. Additional intracellular cytidine followingthe administration of CDP-choline should lead to the increased incorporation of choline already present in brain into membrane PtdCho, which is not MRS-visible, consequently lowering the brain choline resonance below that of pre-treatment values. These results suggest that the cytidine moiety of CDP-choline stimulates phosphatidylcholine synthesisin human brain cell membranes in older subjects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 04:01:00