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Titolo:
PREDICTIVE VALUE OF HIV-1 RNA DETECTION IN PLASMA BY BRANCHED DNA ASSAY DURING LONG-TERM ZIDOVUDINE THERAPY
Autore:
COTTE L; TRABAUD MA; ROUGIER P; BAILLY F; CHAPUIS F; TREPO C;
Indirizzi:
HOP HOTEL DIEU,SERV HEPATOGASTROENTEROL & SIDA,1 PL HOP F-69288 LYON FRANCE INSERM,U271 F-69003 LYON FRANCE HOP HOTEL DIEU,CTR INFORMAT MED F-69288 LYON FRANCE
Titolo Testata:
European journal of clinical microbiology & infectious diseases
fascicolo: 8, volume: 15, anno: 1996,
pagine: 639 - 645
SICI:
0934-9723(1996)15:8<639:PVOHRD>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; INFECTION; QUANTITATION; QUANTIFICATION; LYMPHOCYTES; DISEASE; BURDEN; BLOOD; AIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
L. Cotte et al., "PREDICTIVE VALUE OF HIV-1 RNA DETECTION IN PLASMA BY BRANCHED DNA ASSAY DURING LONG-TERM ZIDOVUDINE THERAPY", European journal of clinical microbiology & infectious diseases, 15(8), 1996, pp. 639-645

Abstract

The predictive value of human immunodeficiency virus type 1 (HIV-1) RNA detection in plasma using branched DNA assay was studied in a subgroup of 36 asymptomatic HIV-1-infected patients enrolled in a multicenter, double-blind, randomized study, Patients were randomized to receive either zidovudine (AZT) 1 g/day or placebo and were monitored for a mean time of 61 months, HIV-1 RNA was detected in plasma using branched DNA assay at months 0, 6, 12, 24, and 36. HIV-1 RNA was detected at levels of greater than or equal to 10(4) RNA eq/ml (eq/ml) in 8.3% of the patients at baseline, and this percentage increased during the first two years in the placebo group only. The detection rate of HIV-1 RNA at three years was 50% in both the AZT and the placebo groups. HIV-1RNA levels ranged from 10(4) to 478 x 10(3) RNA eq/ml, HIV-1 RNA was detected at levels of greater than or equal to 10(4) eq/ml a mean timeof 19 +/- 13 months before progression to AIDS in 76.5% of progressing patients. In a multivariate analysis including baseline CD4+ count, the initial randomization group, HIV-1 RNA detection in plasma, and detection of p24 antigenemia during the first three years of follow-up, the best independent predictors of progression to AIDS at five years and the best independent predictors of death at five years were HIV-1 RNA detection in plasma and p24 antigenemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 12:54:51