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Titolo:
LOSS OF TENDON ORGAN INHIBITION IN PARKINSONS-DISEASE
Autore:
BURNE JA; LIPPOLD OCJ;
Indirizzi:
UNIV SYDNEY,DEPT BIOMED SCI,BOX 170 LIDCOMBE NSW 2141 AUSTRALIA UNIV LONDON,ROYAL HOLLOWAY & BEDFORD NEW COLL,DEPT HUMAN PHYSIOL LONDON ENGLAND
Titolo Testata:
Brain
, volume: 119, anno: 1996,
parte:, 4
pagine: 1115 - 1121
SICI:
0006-8950(1996)119:<1115:LOTOII>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
RIGIDITY; TREMOR;
Keywords:
GOLGI TENDON ORGAN; PARKINSONS DISEASE; AUTOGENIC INHIBITION; TREMOR; MUSCLE RIGIDITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Burne e O.C.J. Lippold, "LOSS OF TENDON ORGAN INHIBITION IN PARKINSONS-DISEASE", Brain, 119, 1996, pp. 1115-1121

Abstract

Electrical stimulation via skin electrodes placed over human tendons results in a reflex inhibition of voluntary activity in the stimulatedmuscle, probably due to activation. of Golgi tendon organ afferents. The characteristics of this response in the extensor digitorum communis (EDC) muscles of subjects with Parkinson's disease were compared with those in age-matched controls. The threshold of the inhibitory response was significantly increased in the patient population compared with controls (159+/-34 V for tremulous patients; 134+/-10 V for rigid patients, 90+/-5.5 V for age-matched controls and 70+/-16 V for all normals). The latency of the inhibitory wave was increased (onset latency was 68.01+/-5.5 ms in patients and 51.5+/-4.9 ms in controls). The duration of I was also increased in patients (60+/-20.8 ms) relative to controls (46+/-11.8 ms). This was associated with slow development of the inhibition with the result that maximal inhibition was delayed by similar to 20 ms. Other features of the patient response were its oscillatory character whereby the initial inhibitory and excitatory components were followed by further prominent peaks and troughs which gave the appearance of continuing response cycles. Such behaviour was not seen in normal records. Also electrical stimulation of the extensor muscle tendon produced concurrent records in the forearm flexor muscle, which resembled those from the stimulated muscle. This was in contrast tonormal records which showed no response in the flexor The possible contribution of a disorder of tendon organ reflexes to the rigidity and tremor of Parkinson's disease is discussed.

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Documento generato il 22/01/20 alle ore 22:13:03