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Titolo:
DETERMINATION OF CYP2C19 PHENOTYPE IN BLACK-AMERICANS WITH OMEPRAZOLE- CORRELATION WITH GENOTYPE
Autore:
MARINAC JS; BALIAN JD; FOXWORTH JW; WILLSIE SK; DAUS JC; OWEN R; FLOCKHART DA;
Indirizzi:
UNIV MISSOURI,SCH MED,DIV CLIN PHARMACOL,DEPT MED,2411 HOLMES ST KANSAS CITY MO 64108 GEORGETOWN UNIV,MED CTR,DEPT MED WASHINGTON DC 20057 GEORGETOWN UNIV,MED CTR,DEPT PHARMACOL WASHINGTON DC 20057 US FDA WASHINGTON DC 20204
Titolo Testata:
Clinical pharmacology and therapeutics
fascicolo: 2, volume: 60, anno: 1996,
pagine: 138 - 144
SICI:
0009-9236(1996)60:2<138:DOCPIB>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
S-MEPHENYTOIN METABOLISM; POLYMORPHIC HYDROXYLATION; CYTOCHROME-P450 2C19; GENETIC-POLYMORPHISM; DRUG-METABOLISM; BLADDER-CANCER; OXIDATION; POPULATION; DEBRISOQUINE; DISPOSITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
J.S. Marinac et al., "DETERMINATION OF CYP2C19 PHENOTYPE IN BLACK-AMERICANS WITH OMEPRAZOLE- CORRELATION WITH GENOTYPE", Clinical pharmacology and therapeutics, 60(2), 1996, pp. 138-144

Abstract

Background: Our objective was to study omeprazole as a single-dose oral probe in the determination of CYP2C19 phenotype in black subjects and to determine the correlation between phenotype and genotype. Methods: This single-dose, open-label outpatient study was conducted at a community-based, university-affiliated teaching hospital outpatient clinic, Study subjects were 100 healthy, unrelated black adults (age range, 18 to 50 years) who were receiving no medications, Baseline omeprazole and 2-hour postingestion omeprazole and 5'-hydroxyomeprazole concentrations mere measured for phenotype determination, Identification of CTP2C19(ml) genotypes were performed with use of the polymerase chain reaction. Results: Results mere obtained for 28 men and 72 women. Ninety-eight subjects were found to be phenotypically extensive metabolizers and two to be poor metabolizers (one man; one smoker), Genotype determination revealed that the two poor metabolizers of omeprazole were homozygous for a single base pair mutation (m(1)/m(1)) in exon 5 of CTP2C19, Twenty-eight of the extensive metabolizers were heterozygous (m(1)/wt) and the remaining 70 were homozygous (wt/wt), No side effects were reported, Conclusions: The 2% prevalence rate of poor CYP2C19 metabolizers in this healthy black population residing in the Midwestern United States is similar to that reported in white subjects and in theShona population of Zimbabwe but much less than in Asian subjects, Omeprazole is a safe and specific probe of the CYP2C19 enzyme system that correlates well with genotype.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:04:29