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Titolo:
EFFECTS OF DIFFERENT MEMBRANES AND DIALYSIS TECHNOLOGIES ON PATIENT TREATMENT TOLERANCE AND NUTRITIONAL PARAMETERS
Autore:
LOCATELLI F; MASTRANGELO F; REDAELLI B; RONCO C; MARCELLI D; LAGRECA G; ORLANDINI G; CORTI M; PONTORIERO G; DIFILIPPO S; ROSSI R; FARMA R; COLANTONIO P; MARTINELLI D; VASILE A; ALLEGRA V; MENGOZZI G; MARTINBIANCO L; BONOMINI V; STEFONI C; COLI L; CIANCIOLO G; DESANCTIS L; DEBLASI V; ALFONSO L; RIZZELLI S; PATRUNO P; BRENDOLAN A; CREPALDI C; CASU MD; MUREDDU S; MAIORCA R; CRISTINELLI L; SETTI G; CAMERINI C; SALVADORI M; BANDINI S; ROSATI A; MANCINI G; PANZETTA G; IANCHE M; DELMASTRO G; COGONI G; ACCALAI GP; SECHI MA; ALLOATTI S; PATERNOSTER G; GAITER A; MANES M; SCHENA FP; PERTOSA G; BOTTALICO D; CANTAFIO S; SALVO E; DAGOSTINO F; GUIDO A; LIMIDO D; BERETTA P; VIGANO MR; DADONE G; VERZETTI G; NAVINO C; BARBE MC; RUVA CE; AMATO M; ATERINI S; IPPOLITO E; SPLENDIANI G; STURNIOLO A; COSTANZI S; PASSALACQUA S; SCATIZZI A; DIMAGGIO A; MONTEMURRO N; VERCELLONE A; SEGOLONI G; PACITTI A; MAFFEI S; SCACCIA F; FINI R; BANDIANI G; ANTIGA G; NICOLINI MA; ASPRONI E; CADINU F; SALVIETTI N; URTI D; LORUSSO P; DANI L; PEONA C; FILIBERTI O; PORCU MC; BARBIERI C; COSTA S; NICROSINI F; MIOLI V; BIBIANO L; CARLETTI P; PANICHI N; MELAPPIONI M; MECCA G; MINGARDI G; PERTICUCCI E; HUBER W; RIEGLER P; GIACON B; ALTIERI P; FERRARA R; BOLASCO PG; CABIDDU G; PAOLILLO A; MORGANTE F; CASCONE C; DELUCA M; DEMIN AM; CAPOTORTO M; UNGARO N; SPECCHIO A; ALBERTAZZI A; DELROSSO G; BONOMINI M; SURIAN M; BONFORTE G; DOZIO B; FRIZZI V; CICIANI AM; RAVAGLIA F; GIACHINO F; BOSTICARDO GM; FRANCISCO M; BIASIOLI S; PETROSINO L; CHIMIENTI S; CRISTOFANO C; PERRONE F; GRASSI C; ORAZI E; BISEGNA S; BRACCHI O; BAZZATO G; TOFFOLETTO PP; TESIO F; FAIMONDI A; BOGGI R; CAMPOGIANI V; GENTILI F; BOLASCO F; PISTIS R; PILLOSU I; STALLONE C; AUCELLA F; PROCACCINI D; AVANZI C; SORBA G; SOLINAS R; COSSU M; DEANGELIS S; RIPANI R; PICCOLI G; MARTINA G; QUARELLO F; BORGHI M; MASSAZZA M; TAGLIAFERRI M; PASCUCCI M; GALIOTTA P; BERTOLUCCI E; SESSA A; CONTE F; SERBELLONI P; VIRGILIO M; DELVINO A; CONTE M; MURA C; CONTI P; PINNA A; NEUMAIR F; BONADONNA A; STANIC L; MUNARETTO G; CICCARELLI P; STEFONI A; BIAGINI M; GERACE MS; CAPECE R; BORDONI E; PETROSELLI F; SCAFFONE V; LOMBARDO V; COPPOLA E; MICUCCI G; CONCETTI M; CAPPONI E; LISI E; RACCOSTA G; SANNA GM; CALVISI L; CHERCHI GL; VITALI P; CASTELLI P; ESTIVI R; SAPORITI E; DECECCO G; LORENZI S; MASCHIO G; TESSITORE N; LOSCHIAVO C; ROVATI C; ANDREOTTI C; GILLI P; DEPAOLI E; NATILI G; PENSALFINI V;
Indirizzi:
OSPED LECCO,DIV NEFROL & DIALISI,VIA GHISLANZONI 22 I-22053 LECCE ITALY OSPED VITO FAZZI,DIV NEPHROL & DIALYSIS LECCE ITALY OSPED SAN GERARDO,DIV NEPHROL & DIALYSIS MONZA ITALY OSPED S BORTOLO,DIV NEPHROL & DIALYSIS VICENZA ITALY FRESENIUS ST,DEPT MED PALAZZO PIGNANO ITALY
Titolo Testata:
Kidney international
fascicolo: 4, volume: 50, anno: 1996,
pagine: 1293 - 1302
SICI:
0085-2538(1996)50:4<1293:EODMAD>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE-RENAL-FAILURE; HEMODIALYSIS-PATIENTS; HIGH-FLUX; BETA-2-MICROGLOBULIN; PHAGOCYTOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
F. Locatelli et al., "EFFECTS OF DIFFERENT MEMBRANES AND DIALYSIS TECHNOLOGIES ON PATIENT TREATMENT TOLERANCE AND NUTRITIONAL PARAMETERS", Kidney international, 50(4), 1996, pp. 1293-1302

Abstract

There is increasing evidence that the biochemical and cellular phenomena induced by blood/membrane/dialysate interactions contribute to dialysis-related intradialytic and long-term complications. However, there is a lack of large, prospective, randomized trials comparing biocompatible and bioincompatible membranes, and convective and diffusive treatment modalities. The primary aim of this prospective, randomized trial was to evaluate whether the use of polysulfone membrane with bicarbonate dialysate offers any advantages (in terms of treatment tolerance, nutritional parameters and pre-treatment beta(2)-microglobulin levels) over a traditional membrane (Cu-prophan(R)). A secondary aim was toassess whether the use of more sophisticated methods consisting of a biocompatible synthetic membrane with different hydraulic permeabilityat different ultrafiltration rate (high-flux hemodialysis and hemodiafiltration) offers any further advantages. Seventy-one Centers were involved and stratified according to the availability of only the first two or all four of the following techniques: Cuprophan(R) hemodialysis(Cu-HD), low flux polysulfone hemodialysis (LfPS-HD), high-flux polysulfone high-flux hemodialysis (HfPS-HD), and high-flux polysulfone hemodiafiltration (HfPS-HDF). The 380 eligible patients were randomized to one of the two or four treatments (132 to Cu-HD, 147 to LfPS-HD, 51 to HfPS-HD and 50 to HfPS-HDF). The follow-up was 24 months. No statistical difference was observed in the algebraic sum of the end points between bicarbonate dialysis with Cuprophan(R) or with low-flux polysulfone, or among the four dialysis methods under evaluation. There was asignificant decrease in pre-dialysis plasma beta(2)-microglobulin levels in high-flux dialysis of 9.04+/-10.46 mg/liter (23%) and in hemodiafiltration of 6.35+/-12.28 mg/liter (16%), both using high-flux polysulfone membrane in comparison with Cuprophan(R) and low-flux polysulfone membranes (P=0.032). The significant decrease in pre-dialysis plasma beta(2)-microglobulin levels could have a clinical impact when one considers that beta(2)-microglobulin accumulation and amyloidosis are important long-term dialysis-related complications.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:34:48