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Titolo:
NEW ASPECTS IN SURFACTANT THERAPY
Autore:
POETS CF;
Indirizzi:
HANNOVER MED SCH,KINDERKLIN,KONSTANTY GUTSCHOW STR D-30623 HANNOVER GERMANY
Titolo Testata:
Monatsschrift fur Kinderheilkunde
fascicolo: 7, volume: 144, anno: 1996,
pagine: 684 - 693
SICI:
0026-9298(1996)144:7<684:NAIST>2.0.ZU;2-1
Fonte:
ISI
Lingua:
GER
Soggetto:
RESPIRATORY-DISTRESS-SYNDROME; INFANTS WEIGHING 500; BLOOD-FLOW VELOCITY; 30 WEEKS GESTATION; EXOGENOUS SURFACTANT; REPLACEMENT THERAPY; BOVINE SURFACTANT; PREMATURE-INFANTS; RANDOMIZED TRIAL; SYNTHETIC SURFACTANT;
Keywords:
EXOGENOUS SURFACTANT; RESPIRATORY DISTRESS SYNDROME; PRETERM INFANTS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
C.F. Poets, "NEW ASPECTS IN SURFACTANT THERAPY", Monatsschrift fur Kinderheilkunde, 144(7), 1996, pp. 684-693

Abstract

After demonstrating the efficacy of exogenous surfactant therapy in the treatment of respiratory distress syndrome (RDS), scientific interest has moved to addressing some of the more practical issues regardingthis therapy. This review summarises the data from recent controlled studies regarding the efficacy of natural vs. artificial surfactant, the best timing of the first dose, the recommended number and quantity of individual doses, the most efficient way to apply these drugs, the costs of this therapy and its potential side effects. These studies demonstrate that (i) natural surfactant preparations are more effective than artificial ones, (ii) survival of intubated neonates of < 30 weeks gestation with suspected RDS is better if they receive their first dose of surfactant as soon as possible after birth, (iii) the optimal initial dose for natural surfactants is 100 mg/kg, whereas subsequent doses may vary from 50-100 mg/kg, (iv) administration of more than 2-3 doses doses not improve longterm clinical outcome, (v) different bolusadministration techniques have no significant effects on surfactant efficacy and side effects, and (vi) total costs per patient are not increased due to a reduced duration of hospital stay. With regard to sideeffects, there appears to be a 50% increase in the risk of pulmonary haemorrhage and a 30 % increase in the risk of intraventricular haemorrhage. The latter, however, is only true for the most immature infants(500-750 g) and does not apply to the more severe stages (grade III-IV). For the future, controlled trials on the combined effects of surfactant and other therapeutic interventions, such as high frequency ventilation, would be desirable.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 08:47:35