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Titolo:
MATURATION OF INTRACRANIAL IMMATURE TERATOMAS - REPORT OF 2 CASES
Autore:
SHAFFREY ME; LANZINO G; LOPES MBS; HESSLER RB; KASSELL NF; VANDENBERG SR;
Indirizzi:
UNIV VIRGINIA,HLTH SCI CTR,DEPT NEUROSURG,BOX 212 CHARLOTTESVILLE VA 22908 UNIV VIRGINIA,NEUROONCOL CTR,DEPT NEUROL SURG CHARLOTTESVILLE VA 00000 UNIV VIRGINIA,VIRGINIA NEUROL INST,DIV NEUROPATHOL CHARLOTTESVILLE VA00000
Titolo Testata:
Journal of neurosurgery
fascicolo: 4, volume: 85, anno: 1996,
pagine: 672 - 676
SICI:
0022-3085(1996)85:4<672:MOIIT->2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
OVARY; RETROCONVERSION; TUMORS; CHILDHOOD;
Keywords:
TERATOMA; PROGNOSIS; INTRACRANIAL NEOPLASM; CHEMOTHERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
M.E. Shaffrey et al., "MATURATION OF INTRACRANIAL IMMATURE TERATOMAS - REPORT OF 2 CASES", Journal of neurosurgery, 85(4), 1996, pp. 672-676

Abstract

Immature teratomas arising within the central neuraxis are rare neoplasms. These tumors contain diverse cell lineages that retain an embryonal character and display phenotypic differentiation attributed to thethree classic germ layers. The clinical management of these lesions is unclear, due in part to their low incidence and to an incomplete understanding of their natural history. Although the potential for phenotypic differentiation and cellular maturation within immature teratomasarising in the gonads is well documented, this has not been describedin the intracranial tumors. In the present report, the authors describe two cases of intracranial immature teratomas, one involving the pineal region and the other involving the left frontotemporal lobes, which underwent cellular differentiation and maturation. At initial resection, the tumors from both cases were composed predominantly of primitive neuroepithelial tissue that was admired with immature and differentiating mesenchymal and epithelial structures. No foci of germinoma, endodermal sinus, choriocarcinoma, or embryonal carcinoma tissue were present. Subsequent resections in both cases revealed an absence of immature tissue. The tumor in Case 1 contained only differentiated epithelial and mesenchymal tissue with no neuroepithelial component, whereas the tumor in Case 2 demonstrated abundant mature neuronal and glial tissue. These two cases from different intracranial sites suggest that spontaneous maturation may be a significant aspect of the natural history of intracranial immature teratomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:15:21