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Titolo:
MODULATION OF PUTRESCINE TRANSPORT IN RAT INTESTINAL BRUSH-BORDER MEMBRANE-VESICLES BY FASTING AND REFEEDING
Autore:
BRACHET P; PREVOTEAU H; MATHE V; TOME D;
Indirizzi:
INRA,FAC SCI PHARMACEUT & BIOL,UNITE NUTR CELLULAIRE & MOL F-63122 STGENES CHAMPANE FRANCE PARC CLUB UNIV,LAB RECH EUROLYSINE ORSAY FRANCE
Titolo Testata:
Digestion
fascicolo: 5, volume: 57, anno: 1996,
pagine: 374 - 381
SICI:
0012-2823(1996)57:5<374:MOPTIR>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CRYPT CELL-LINE; ORNITHINE DECARBOXYLASE; GLUCOSE TRANSPORT; DIAMINE OXIDASE; MUCOSAL GROWTH; POLYAMINES; SYSTEMS; STARVATION; FOOD;
Keywords:
POLYAMINES; UPTAKE; SMALL INTESTINE; TRANSPORT KINETICS; STARVATION; FASTING REFEEDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
P. Brachet et al., "MODULATION OF PUTRESCINE TRANSPORT IN RAT INTESTINAL BRUSH-BORDER MEMBRANE-VESICLES BY FASTING AND REFEEDING", Digestion, 57(5), 1996, pp. 374-381

Abstract

Fasting and refeeding dramatically alter small intestinal mucosal growth which is greatly dependent on polyamine biosynthesis and transport. The aim of this study was therefore to examine the uptake of the diamine putrescine by brush-border membrane vesicles from the small intestine of rats fasted for 3 days or refed a standard diet after a periodof fasting. While the Michaelis-Menten constant (K-m) was essentiallyunaltered, the maximum velocity (V-max) for putrescine uptake was 1.85-fold higher in fasted animals than in ad libitum-fed controls. Refeeding fasted rats for 24 h caused a 31% decrease in the V-max value that, however, remained 1.27-fold higher than in control rats, while the K-m value was still unchanged. Fasting rats or refeeding rats after a period of fasting caused only a 13 or 17% increase, respectively, in the value of the constant for the nonsaturable component (P) of putrescine transport relative to the corresponding control condition. Our study also confirms that both the mucosal polyamine biosynthesis and intestinal content are altered by fasting. We suggest that an increased uptake activity may have a conservative role by preventing a substantialloss of tissue polyamines during fasting.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 14:41:40