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Titolo:
TOLERANCE TO THE ANXIOLYTIC EFFECTS OF THE TRIAZOLOBENZODIAZEPINES TRIAZOLAM AND ALPRAZOLAM, AS MEASURED BY THE INGESTION OF A HYPERTONIC SODIUM-CHLORIDE SOLUTION IN RATS
Autore:
BARBARITO EJ; LAU CE; FALK JL;
Indirizzi:
RUTGERS STATE UNIV,DEPT PSYCHOL BUSCH NEW BRUNSWICK NJ 08903 RUTGERS STATE UNIV,DEPT PSYCHOL NEW BRUNSWICK NJ 08903
Titolo Testata:
The Journal of pharmacology and experimental therapeutics
fascicolo: 3, volume: 278, anno: 1996,
pagine: 1201 - 1208
SICI:
0022-3565(1996)278:3<1201:TTTAEO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PANIC DISORDER; PHYSICAL-DEPENDENCE; ABUSE LIABILITY; BENZODIAZEPINES; DIAZEPAM; FOOD; BEHAVIOR; ANXIETY; CHLORDIAZEPOXIDE; DISCONTINUATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
E.J. Barbarito et al., "TOLERANCE TO THE ANXIOLYTIC EFFECTS OF THE TRIAZOLOBENZODIAZEPINES TRIAZOLAM AND ALPRAZOLAM, AS MEASURED BY THE INGESTION OF A HYPERTONIC SODIUM-CHLORIDE SOLUTION IN RATS", The Journal of pharmacology and experimental therapeutics, 278(3), 1996, pp. 1201-1208

Abstract

Rats were adapted to a water-deprivation regimen that allowed daily 1-hr drinking sessions of a single fluid, either 1.5% NaCl solution or water. Oral, presession, acute doses of triazolam (0.05-1.6 mg/kg) or alprazolam (0.4-6.4 mg/kg) produced dose-related increases in session NaCl solution ingestion. The relative potencies found for these two drugs approximated their relative K-i values reported in the literature. The increased ingestion produced in this and other experiments by anxiolytic agents is presented as an alternative way of evaluating punishment attenuation, and hence anxiolytic activity. Chronic oral dosing (every 2nd day) with triazolam (0.2 mg/kg) or alprazolam (1.2 mg/kg) led, after several weeks, to partial, but surmountable, tolerance to theincreased NaCl solution ingestion produced by these drugs, which was confirmed by a rightward shift in the dose-effect relations. During chronic dosing, no corresponding declines in the independently evaluatedincreases in water intake produced by these drugs occurred. Abrupt drug discontinuation produced a precipitous decrease in NaCl solution intake, with subsequent recovery. For triazolam, the initial discontinuation decrease in intake to below the original base line suggested the possible accrual of a mild physiological dependence under this moderate chronic dose regimen.

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Documento generato il 02/04/20 alle ore 00:16:48