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Titolo:
THE EFFECTS OF MORPHINE ON CARRAGEENAN-INDUCED SPINAL C-FOS EXPRESSION ARE COMPLETELY BLOCKED BY BETA-FUNALTREXAMINE, A SELECTIVE MU-OPIOIDRECEPTOR ANTAGONIST
Autore:
HONORE P; BURITOVA J; BESSON JM;
Indirizzi:
INSERM,U161,2 RUE ALESIA F-75014 PARIS FRANCE EPHE F-75014 PARIS FRANCE
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 732, anno: 1996,
pagine: 242 - 246
SICI:
0006-8993(1996)732:1-2<242:TEOMOC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-LIKE IMMUNOREACTIVITY; CORD NEURONS; NOXIOUS-STIMULATION; RAT; AGONISTS; STIMULUS; INVIVO; PAIN;
Keywords:
ANTINOCICEPTION; C-FOS; SPINAL CORD; MORPHINE; CARRAGEENAN; MU-OPIOID RECEPTOR; BETA-FUNALTREXAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
P. Honore et al., "THE EFFECTS OF MORPHINE ON CARRAGEENAN-INDUCED SPINAL C-FOS EXPRESSION ARE COMPLETELY BLOCKED BY BETA-FUNALTREXAMINE, A SELECTIVE MU-OPIOIDRECEPTOR ANTAGONIST", Brain research, 732(1-2), 1996, pp. 242-246

Abstract

We have demonstrated that pre-administered morphine (3 mg/kg, i.v.) decreased spinal c-Fos expression induced 2 h after intraplantar carrageenin (55 +/- 5% reduction, P < 0.0001). These effects were completelyblocked by pre-administered beta-funaltrexamine (10 mg/kg, i.v., 24 hprior to stimulation) a selective long-lasting mu-opioid receptor antagonist. In conclusion, these results clearly demonstrate that the effects of morphine on noxiously-evoked spinal c-Fos expression are essentially mediated via mu-opioid receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 11:58:35