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Titolo:
A MODEL FOR QUANTIFICATION OF PERFUSION IN PULSED LABELING TECHNIQUES
Autore:
CALAMANTE F; WILLIAMS SR; VANBRUGGEN N; KWONG KK; TURNER R;
Indirizzi:
INST CHILD HLTH,RCS UNIT BIOPHYS,30 GUILFORD ST LONDON WC1N 1EH ENGLAND INST CHILD HLTH,RCS UNIT BIOPHYS LONDON WC1N 1EH ENGLAND MASSACHUSETTS GEN HOSP,NMR CTR,DEPT RADIOL CHARLESTOWN MA 02129
Titolo Testata:
NMR in biomedicine
fascicolo: 2, volume: 9, anno: 1996,
pagine: 79 - 83
SICI:
0952-3480(1996)9:2<79:AMFQOP>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; RAT-BRAIN PERFUSION; ARTERIAL WATER; SPIN INVERSION; MR; STIMULATION; SATURATION; T1; T2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
F. Calamante et al., "A MODEL FOR QUANTIFICATION OF PERFUSION IN PULSED LABELING TECHNIQUES", NMR in biomedicine, 9(2), 1996, pp. 79-83

Abstract

A model for quantification of perfusion in pulsed labelling techniques is described, based on solving the modified Bloch equation includingthe effects of flow. The model is designed to fit experimental data acquired in two separate measurements (inversion and control, or selective and non-selective inversions) for different inversion times using a biexponential. Although the signal contrast is 50% less than the continuous labelling technique, it seems more appropriate for human studies because of its lower power deposition, shorter transit time and theuse of an interleaved acquisition. The importance is shown of including in the model the difference in relaxation time between blood and tissue. Neglecting this difference can lead to an overestimation of flow, which can be as big as 100% in white matter and 20% in grey matter.

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Documento generato il 27/09/20 alle ore 00:58:24