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Titolo:
INVARIANCE OF THE RESISTANCE TO VENOUS RETURN TO CAROTID-SINUS BAROREFLEX CONTROL
Autore:
HATANAKA T; POTTS JT; SHOUKAS AA;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,DEPT BIOMED ENGN,720 RUTLAND AVE BALTIMOREMD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT BIOMED ENGN BALTIMORE MD 21205
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 3, volume: 40, anno: 1996,
pagine: 1022 - 1030
SICI:
0363-6135(1996)40:3<1022:IOTRTV>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC VASCULAR BED; BARORECEPTOR REFLEX; HYPERTENSIVE DOGS; RAT INTESTINE; PRESSURE; EPINEPHRINE; CAPACITANCE; ARTERIAL; DIAMETER; FLOW;
Keywords:
CARDIAC OUTPUT; ARTERIAL COMPLIANCE; VENOUS COMPLIANCE; ARTERIAL RESISTANCE; VENOUS RESISTANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
T. Hatanaka et al., "INVARIANCE OF THE RESISTANCE TO VENOUS RETURN TO CAROTID-SINUS BAROREFLEX CONTROL", American journal of physiology. Heart and circulatory physiology, 40(3), 1996, pp. 1022-1030

Abstract

Despite the well-established fact that the carotid sinus baroreflex system has profound control over the physical properties of the systemic circulation, the resistance to venous return (RVR) seems to be invariant of such control. We hypothesized that this apparent paradox may be explained from the baroreflex changes in systemic arterial compliance. In 12 pentobarbital-anesthetized mongrel dogs, RVR was measured at controlled carotid sinus pressures (CSP) of 50 and 200 mmHg with normal and artificially increased arterial compliance. Arterial compliance was determined from the arterial pressure decay when systemic blood flow was stopped with total vena caval occlusion. Changing CSP between 50 and 200 mmHg changed RVR significantly only under the condition of artificially increased arterial compliance. A four-parameter lumped model of the systemic circulation revealed that the baroreflex changes inarterial compliance and arterial resistance, which occurred in opposite directions, prevented a change in RVR when CSP was changed. The data also suggested that similar to 75% of RVR was attributed to large and conduit veins, the resistances along which were insensitive to baroreflex control. We concluded that the invariance of RVR results from a combination of 1) baroreflex change in the arterial compliance, 2) baroreflex insensitivity of the resistance along large and conduit veins,and 3) spatially distinct location between the major site of reflex change in capacitance and the major site of compliance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 16:22:53