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Titolo:
NEONATAL INSULT TO THE HIPPOCAMPAL REGION AND SCHIZOPHRENIA - A REVIEW AND A PUTATIVE ANIMAL-MODEL
Autore:
BEAUREGARD M; BACHEVALIER J;
Indirizzi:
UNIV TEXAS,HLTH SCI CTR,DEPT ANAT & NEUROBIOL,6431 FANNIN HOUSTON TX 77225 UNIV TEXAS,HLTH SCI CTR,DEPT ANAT & NEUROBIOL HOUSTON TX 77225
Titolo Testata:
Canadian journal of psychiatry
fascicolo: 7, volume: 41, anno: 1996,
pagine: 446 - 456
SICI:
0706-7437(1996)41:7<446:NITTHR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CEREBRAL BLOOD-FLOW; DORSOLATERAL PREFRONTAL CORTEX; MAGNETIC-RESONANCE SPECTROSCOPY; CONTINUOUS PERFORMANCE-TEST; BRAIN GLUCOSE-METABOLISM; TEMPORAL-LOBE STRUCTURES; LIMBIC SYSTEM; PARAHIPPOCAMPAL GYRUS; PYRAMIDAL CELL;
Keywords:
NEONATAL HIPPOCAMPAL LESION; SOCIAL INTERACTIONS; STEREOTYPIES; SCHIZOPHRENIA; MONKEYS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
144
Recensione:
Indirizzi per estratti:
Citazione:
M. Beauregard e J. Bachevalier, "NEONATAL INSULT TO THE HIPPOCAMPAL REGION AND SCHIZOPHRENIA - A REVIEW AND A PUTATIVE ANIMAL-MODEL", Canadian journal of psychiatry, 41(7), 1996, pp. 446-456

Abstract

Objective: To review the mounting evidence implicating early hippocampal dysfunction in the pathogenesis and the pathophysiology of schizophrenia. An account is made of recent neurodevelopmental hypotheses indicating how an early dysfunction of the hippocampal region disrupts maturational events in brain systems connected to that structure, thus inducing dysfunctional connectional development Finally, an animal model is presented. Method: Socioemotional behaviour of monkeys (Macaca mulatta) with selective neonatal hippocampal lesions was assessed by analyzing their interactions with their age-matched controls at 2 months,6 months, and 5 to 8 years of age and by comparing the social interactions at each age with those of normal controls paired together. Results: At 2 months of age, monkeys with neonatal hippocampal lesions presented minor disturbances in initiation of social interactions. These subtle changes of behaviour were less evident at 6 months, although by that age, the operated monkeys displayed more withdrawals in response to an increase in aggressive responses from their unoperated peers. Inadulthood, the amount of time spent by the hippocampectomized monkeysin social contacts with their normal peers decreased markedly. In addition, operated monkeys exhibited more locomotor stereotypies than normal controls. Conclusion: These experimental findings indicate that the rime-course and nature of the behavioural disturbances resulting from early trauma to the hippocampal region have some similarities with the clinical symptoms of schizophrenic patients and the typical time-course of the disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 21:46:48