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Titolo:
APOPTOSIS AS A FUNCTION OF OVARIAN RESERVE IN WOMEN UNDERGOING IN-VITRO FERTILIZATION
Autore:
SEIFER DB; GARDINER AC; FERREIRA KA; PELUSO JJ;
Indirizzi:
OHIO STATE UNIV,MED CTR,DEPT OBSTET & GYNECOL,DIV REPROD ENDOCRINOL,5TH FLOOR,MEANS HALL COLUMBUS OH 43210 BROWN UNIV,SCH MED PROVIDENCE RI 02912 UNIV CONNECTICUT,CTR HLTH,DEPT OBSTET & GYNECOL FARMINGTON CT 00000
Titolo Testata:
Fertility and sterility
fascicolo: 4, volume: 66, anno: 1996,
pagine: 593 - 598
SICI:
0015-0282(1996)66:4<593:AAAFOO>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
STIMULATING-HORMONE LEVEL; GRANULOSA-CELL APOPTOSIS; INVITRO FERTILIZATION; FOLLICULAR ATRESIA; DEATH; AGE; CYCLE; PROGESTERONE; REGRESSION; PREGNANCY;
Keywords:
GRANULOSA CELLS; APOPTOSIS; OVARIAN RESERVE; FLOW CYTOMETRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
D.B. Seifer et al., "APOPTOSIS AS A FUNCTION OF OVARIAN RESERVE IN WOMEN UNDERGOING IN-VITRO FERTILIZATION", Fertility and sterility, 66(4), 1996, pp. 593-598

Abstract

Objective: To test the hypothesis that preovulatory follicles from women with diminished ovarian reserve contain fewer numbers of luteinized granulosa cells and have a greater percentage of cells undergoing apoptosis as compared with women with uncompromised ovarian reserve undergoing superovulation for IVF-ET.Design: Comparative study. Setting: Academic clinical practice. Patients: Luteinized granulosa cell counts were determined from follicular aspirates harvested from 19 women withday 3 serum FSH less than or equal to 6 mIU/mL (conversion factor to SI unit, 1.00) and from 15 women with FSH levels greater than or equalto 10 mIU/mL. The second part examined the percent of proliferating and apoptotic cells harvested from nine women with day 3 serum FSH lessthan or equal to 6 mIU/mL mt and from eight women with FSH levels greater than or equal to 10 mIU/mL. Main Outcome Measures: Cell counts byhemacytometer and percent of proliferating and of apoptotic granulosacells by flow cytometry. Results: The mean number of viable cells isolated per follicle were 2.7 x 10(5) (95% confidence interval [CI] 2.3 to 3.1 x 10(5)) from the low FSH group and 1.8 x 10(5) (95% CI 1.4 to 2.3 x 10(5)) from the high FSH group. Although the percentage of proliferating cells was the same, the mean percentage of apoptotic cells was 0.5% (95% CI 0.2% to 1.4%) from the low group and 2.0% (95% CI 1.1% to 3.7%) from the high group. Conclusions: Women undergoing TVF with day 3 serum FSH greater than or equal to 10 mIU/mL have preovulatory follicles with fewer luteinized granulosa cells and an increase in the percentage of cells undergoing apoptosis as compared with women with day 3 serum FSH less than or equal to 6 mIU/mL.

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Documento generato il 29/11/20 alle ore 17:52:31