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Titolo:
DIFFERENTIATION OF PRIMARY AND SECONDARY CUTANEOUS B-CELL LYMPHOMA BYSOUTHERN BLOT ANALYSIS
Autore:
SEPP N; WEYRER K; HAUN M; ZELGER B; THALER J; FABER V; FRITSCH P; GRUNEWALD K;
Indirizzi:
INNSBRUCK UNIV,DEPT DERMATOL,ANICHSTR 35 A-6020 INNSBRUCK AUSTRIA INNSBRUCK UNIV,LAB MOL GENET & DIAGNOST A-6020 INNSBRUCK AUSTRIA INNSBRUCK UNIV,DEPT MED A-6020 INNSBRUCK AUSTRIA
Titolo Testata:
American journal of clinical pathology
fascicolo: 6, volume: 106, anno: 1996,
pagine: 749 - 757
SICI:
0002-9173(1996)106:6<749:DOPASC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; NON-HODGKINS-LYMPHOMA; KAPPA-LAMBDA ANALYSIS; MALIGNANT-LYMPHOMA; LYMPHOPROLIFERATIVE DISEASE; IMMUNOGLOBULIN GENES; FOLLICULAR LYMPHOMA; MYCOSIS-FUNGOIDES; PERIPHERAL-BLOOD; SKIN;
Keywords:
PRIMARY CUTANEOUS B-CELL LYMPHOMA; SOUTHERN BLOT ANALYSIS; SECONDARY CUTANEOUS B-CELL LYMPHOMA; PERIPHERAL BLOOD; BONE MARROW;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
N. Sepp et al., "DIFFERENTIATION OF PRIMARY AND SECONDARY CUTANEOUS B-CELL LYMPHOMA BYSOUTHERN BLOT ANALYSIS", American journal of clinical pathology, 106(6), 1996, pp. 749-757

Abstract

Malignant B-cell lymphomas represent a heterogenous group of lymphoreticular disorders that involve the skin in about 20% of reported cases. Skin involvement may be primary or secondary tie, the result of hematogenous spread). Primary cutaneous B-cell lymphomas (PCBCLs) are thought to take a comparatively favorable course, respond readily to nonaggressive treatment, and lack evidence of extracutaneous spread. Nine primary B-cell lymphomas (7 centrocytic or centroblastic follicular, 1 immunoblastic, 1 centroblastic), three secondary (follicular) cutaneous B-cell lymphomas (SCBCLs) and two pseudolymphomas were studied, Staging revealed that bone marrow was involved only in SCBCLs. Centrocyteswere detected in blood smear preparations of all SCBCLs. All lymphomas were treated with local irradiation. Patients with primary centroblastic and immunoblastic cutaneous lymphomas and those with secondary lymphomas received additional chemotherapy. Pseudolymphomas were treatedby simple excision. Patients were monitored on average for 55 months. During this period, no patients with PCBCLs exhibited cutaneous relapses or hematogenous spread, In contrast, all patients with SCBCLs experienced cutaneous relapses. Peripheral blood, bone marrow, and skin samples from all patients were subjected to Southern blot analysis usinga JH probe. Clonal rearrangement was found in all skin samples investigated except specimens from pseudolymphomas. Peripheral blood and bone marrow samples were positive in SCBCLs (the rearrangement pattern was different from that of the skin samples for two of the three patients), whereas it was negative in all PCBCLs and pseudolymphomas. In conclusion, Southern blot analysis of peripheral blood may be useful in differential diagnosis of PCBCLs and SCBCLs and a prognostic marker, Furthermore, these data confirm the comparatively favorable clinical course of PCBCLs and suggest that in these cases, local irradiation can beconsidered adequate treatment, whereas SCBCLs require additional systemic therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:22:07