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Titolo:
DECREASED ILEAL MUSCLE CONTRACTILITY AND INCREASED NOS-II EXPRESSION INDUCED BY LIPOPOLYSACCHARIDE
Autore:
WEISBRODT NW; PRESSLEY TA; LI YF; ZEMBOWICZ MJ; HIGHAM SC; ZEMBOWICZ A; LODATO RF; MOODY FG;
Indirizzi:
UNIV TEXAS,SCH MED,DEPT INTEGRAT BIOL,POB 20708 HOUSTON TX 77225 UNIV TEXAS,SCH MED,DEPT SURG HOUSTON TX 77225 UNIV TEXAS,SCH MED,TRAUMA RES CTR HOUSTON TX 77225
Titolo Testata:
American journal of physiology: Gastrointestinal and liver physiology
fascicolo: 3, volume: 34, anno: 1996,
pagine: 454 - 460
SICI:
0193-1857(1996)34:3<454:DIMCAI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; VASCULAR SMOOTH-MUSCLE; NA+-K+-ATPASE; L-ARGININE; INDUCTION; ENDOTOXIN; RAT; DNA; CLONING; RNA;
Keywords:
RAT; NITRIC OXIDE SYNTHASE MESSENGER RIBONUCLEIC ACID; NITRIC OXIDE SYNTHASE ANTIBODY; SMOOTH MUSCLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
N.W. Weisbrodt et al., "DECREASED ILEAL MUSCLE CONTRACTILITY AND INCREASED NOS-II EXPRESSION INDUCED BY LIPOPOLYSACCHARIDE", American journal of physiology: Gastrointestinal and liver physiology, 34(3), 1996, pp. 454-460

Abstract

This study was designed to determine if an increase in nitric oxide synthase (NOS) activity induced by lipopolysaccharide (LPS) is associated with increases in NOS II protein and mRNA abundance and with altered ileal longitudinal muscle contractility. Strips of muscle taken fromLPS-treated, but not control, animals exhibited reduced in vitro contractility when L-arginine was a component of the physiological salt solution. This reduction was reversed by N-omega-nitro-L-arginine (L-NNA), a competitive inhibitor of NOS. Full-thickness segments of jejunum,ileum, and colon taken 5 h after LPS injection exhibited increased NOS activity, NOS II immunoreactivity, and NOS II mRNA abundance. Increased NOS II immunoreactivity and mRNA abundance also were detected in ileal muscle strips taken from LPS-treated animals. These data confirm the reported effects of LPS on intestinal NOS activity and indicate that it can be attributed, at least in part, to an increase in NOS II mRNA and protein abundance. Furthermore, the data suggest that an LPS-induced increase in NOS II may lead to a decrease in ileal muscle contractility.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 16:20:16